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Journal of Neuro-Oncology

, Volume 4, Issue 4, pp 329–336 | Cite as

Establishment of interleukin 2 dependent cytotoxic T lymphocyte cell line specific for autologous brain tumor and its intracranial administration for therapy of the tumor

  • Toshiki Kitahara
  • Osamu Watanabe
  • Akira Yamaura
  • Hiroyasu Makino
  • Takashi Watanabe
  • Gen Suzuki
  • Ko Okumura
Article

Abstract

Autologous brain tumor specific CTLs were induced from the patient's PBL by a mixed lymphocyte-tumor culture, and were maintained for more than 2 months in a medium containing exogenous ILr2. The autologous T cell line containing specific CTL was administered into the tumor-bed for the treatment of malignant glioma. In 2 cases out of 5, tumors regressed more than 50% in diameter. One of these patients is still alive now with full of his social activities, and it is 104 weeks after the initiation of the immunotherapy. Autologous T cell lines were safely administered in all cases without any complications nor toxicities.

Keywords

adoptive immunotherapy cytotoxic T lymphocyte interleukin 2 brain tumor 

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Copyright information

© Martinus Nijhoff Publishers 1987

Authors and Affiliations

  • Toshiki Kitahara
    • 1
  • Osamu Watanabe
    • 2
  • Akira Yamaura
    • 1
  • Hiroyasu Makino
    • 1
  • Takashi Watanabe
    • 3
  • Gen Suzuki
    • 4
  • Ko Okumura
    • 5
  1. 1.Department of Neurological SurgeryChiba University School of MedicineChibashi, ChibaJapan
  2. 2.Department of NeurosurgeryChiba Rosai HospitalJapan
  3. 3.Department of NeurosurgeryTokyo Metropolitan Ebara General HospitalJapan
  4. 4.Division of Radiation HealthNational Institute of Radiological SciencesJapan
  5. 5.Department of ImmunologyJuntendo University School of MedicineJapan

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