Human Genetics

, Volume 86, Issue 5, pp 509–514

The human aldose reductase gene maps to chromosome region 7q35

  • Alexander Graham
  • Paul Heath
  • John E. N. Morten
  • Alexander F. Markham
Original investigations

DOI: 10.1007/BF00194644

Cite this article as:
Graham, A., Heath, P., Morten, J.E.N. et al. Hum Genet (1991) 86: 509. doi:10.1007/BF00194644

Summary

The human aldose reductase (AR) gene has been mapped to chromosome 7 using the polymerase chain reaction to specifically amplify the human AR sequence in hamster/human hybrid DNA and also in mouse/ human monochromosome hybrids. The assignment to chromosome 7 was confirmed by in situ hybridisation to human metaphase chromosomes using a novel, rapid hybridisation, method giving a regional localisation at 7q35.

Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Alexander Graham
    • 1
  • Paul Heath
    • 1
  • John E. N. Morten
    • 1
  • Alexander F. Markham
    • 1
  1. 1.Biotechnology DepartmentICI PharmaceuticalsMacclesfieldUK

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