Human Genetics

, Volume 85, Issue 6, pp 651–654

The human aminopeptidase N gene: isolation, chromosome localization, and DNA polymorphism analysis

  • Valerie M. Watt
  • Huntington F. Willard
Original Investigations


DNA encoding the human aminopeptidase N (EC gene (PEPN) was first isolated using rat cDNA probes and then used in Southern analysis of DNA from mouse-human somatic cell hybrids to assign this gene to the long-arm region (q11-qter) of human chromosome 15. This human genomic DNA probe detects a frequent DraIII polymorphism that is a useful marker for human chromosome 15.


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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Valerie M. Watt
    • 1
  • Huntington F. Willard
    • 2
  1. 1.Department of PhysiologyUniversity of TorontoTorontoCanada
  2. 2.Department of GeneticsStanford UniversityStanfordUSA

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