Human Genetics

, Volume 96, Issue 4, pp 481–482 | Cite as

Precise localization of the human thyroxine-binding globulin gene to chromosome Xq22.2 by fluorescence in situ hybridization

  • Yuichi Mori
  • Yoshitaka Miura
  • Yutaka Oiso
  • Seo Hisao
  • Kozaki Takazumi
Short Communication


The human thyroxine-binding globulin (TBG) gene has been localized to X chromosome (Xq22.2) by in situ hybridization using a biotinylated gDNA probe. This is consistent with previous mapping of the TBG gene to chromosome Xq21-q22.


Internal Medicine Metabolic Disease Precise Localization Previous Mapping Globulin Gene 
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  1. Flink IL, Bailey TJ, Gustafson TA, Markham BE, Morkin E (1986) Complete amino acid sequence of human thyroxine-binding globulin deduced from cloned DNA: close homology to the serine antiproteases. Proc Natl Acad Sci USA 83:7708–7712Google Scholar
  2. Hayashi Y, Mori Y, Janssen O, Sunthornthepvarakul T, Weiss RE, Takeda K, Weinberg M, Seo H, Bell GI, Refetoff S (1993) Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation. Mol Endocrinol 7:1049–1060Google Scholar
  3. Hori T, Takahashi E, Ayusawa D, Takeishi H, Kaneda S, Seno T (1990) Regional assignment of the human thymidine synthase (TS) gene to chromosome band 18p11. 32 by nonisotopic in situ hybridization. Hum Genet 85:576–580Google Scholar
  4. Mori Y, Seino S, Takeda K, Flink IL, Murata Y, Bell GI, Refetoff S (1989) A mutation causing reduced biological activity and stability of thyroxine-binding globulin probably as a result of abnormal glycosylation of the molecule. Mol Endocrinol 3:575–579Google Scholar
  5. Mori Y, Takeda K, Charbonneau M, Refetoff S (1990) Replacement of Leu227 by Pro in thyroxine-binding globulin (TBG) is associated with complete TBG deficiency in three of eight families with this inherited defect. J Clin Endocrinol Metab 70:804–809Google Scholar
  6. Refetoff S (1979) Thyroid hormone transport. In: DeGroot LJ (ed) Endocrinology. Grune and Stratton, New York, pp 347–356Google Scholar
  7. Refetoff S (1989) Inherited thyroxine-binding globulin abnormalities in man. Endocrinol Rev 10:275–293Google Scholar
  8. Takahashi E, Hori T, O'Connell P, Leppert M, White R (1990) R-banding and nonisotopic in situ hybridization: precise localization of the human type II collagen gene (COL2A1). Hum Genet 86:14–16Google Scholar
  9. Takahashi E, Hori T, O'Connell P, Leppert M, White R (1991) Mapping of the MYC gene to band 8q24. 12-q24. 13 by R-banding and distal to FRA(8)(q24. 11), FRA8E, by fluorescence in situ hybridization. Cytogenet Cell Genet 57:109–111Google Scholar
  10. Trent JM, Flink IL, Morkin E, Van Tuinen P, Ledbetter DH (1987) Localization of the human thyroxine-binding globulin gene to he long arm of the X chromosome (Xq21–22). Am J Hum Genet 41:428–435Google Scholar
  11. Viegas-Pequignot E, Dutrillaux B (1978) Une methode simple pour obtenir des prophases et des prometaphases. Ann Génét (Paris) 21:122–125Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Yuichi Mori
    • 1
  • Yoshitaka Miura
    • 2
  • Yutaka Oiso
    • 2
  • Seo Hisao
    • 3
  • Kozaki Takazumi
    • 4
  1. 1.4th Dpt. of Internal MedicineAichi Medical UniversityAichi-KenJapan
  2. 2.The First Department of Internal MedicineNagoya University School of MedicineNagoyaJapan
  3. 3.Department of Endocrinology and MetabolismResearch Institute of Environmental Medicine, Nagoya UniversityNagoyaJapan
  4. 4.Center for Molecular Biology and Cytogenetics Genetic Research Division Diagnosis GroupSRL, Inc.TokyoJapan

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