Advertisement

Immunogenetics

, Volume 41, Issue 1, pp 40–43 | Cite as

The closely linked genes encoding the myeloid nuclear differentiation antigen (MNDA) and IFI16 exhibit contrasting haemopoietic expression

  • Michelle J. Dawson
  • Joseph A. Trapani
  • Robert C. Briggs
  • Jillian K. Nicholl
  • Grant R. Sutherland
  • Elizabeth Baker
Brief Communication

Keywords

Differentiation Antigen Nuclear Differentiation Nuclear Differentiation Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Briggs, J. A., Burrus, G. R., Stickney, B. D., and Briggs, R. C. Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon α. J Cell Biochem 49: 82–92, 1992Google Scholar
  2. Briggs, R. C., Dworkin, L., Briggs, J., Dessypris, E., Stein, J., Stein, G., and Lian, G. Interferon-α selectively affects expression of the human myeloid cell nuclear differentiation antigen in late stage cells in the monocytic but not the granulocytic lineage. J Cell Biochem 54: 198–206, 1994aGoogle Scholar
  3. Briggs, R. C., Briggs, J. A., Ozer, J., Sealy, L., Dworkin, L. L., Kingsmore, S. F., Seldin, M. F., Kaur, G. P., Athwal, R. S., and Dessypris, E. N. The human myeloid cell nuclear differentiation antigen gene is one of at least two related interferon-inducible genes located at chromosome 1q that are expressed specifically in hematopoietic cells. Blood 83: 2153–2162, 1994bGoogle Scholar
  4. Callen, D. F., Baker, E., Eyre, H. J., Chernos, J. E., Bell, J. A., and Sutherland, G. R. Reassessment of two apparent deletions of chromosome 16p to an ins(11: 16) and a t(1 : 16) by chromosome painting. Ann Génét 33: 219–221, 1990Google Scholar
  5. Choubey, D. and Lengyel, P. Interferon action: nucleolar and nucleoplasmic localization of the interferon-inducible 72-kDa protein that is encoded by the Ifi 204 gene from the Gene 200 cluster. J Cell Biol 116: 1333–1341, 1992Google Scholar
  6. Choubey, D. and Lengyel, P. Interferon action: Cytoplasmic and nuclear localization of the interferon-inducible 52-kDa protein that is encoded by the Ifi 202 gene from the Gene 200 cluster. J Interferon Res 13: 43–52, 1993Google Scholar
  7. Choubey, D., Snoddy, J., Chaturvedi, V., Toniato, E., Opdenakker, G., Thakur, A., Samanta, H., Engel, D. A., and Lengyel, P. Interferons as gene activators: indications for repeated gene duplication during the evolution of a cluster of interferon-activatable genes on murine chromosome 1. J Biol Chem 264: 17182–17189, 1989Google Scholar
  8. Cousar, J. B. and Briggs, R. C. Expression of human myeloid cell nuclear differentiation antigen (MNDA) in acute leukemias. Leuk Res 14: 915–920, 1990Google Scholar
  9. Dawson, M. J. and Trapani, J. A. The IFI 16 gene encodes a nuclear protein whose expression is induced by interferons in human myeloid leukemia cell lines. J Cell Biochem, in pressGoogle Scholar
  10. Engel, D. A., Samanta, H., Brawner, M. E., and Lengyel, P. Interferon action: transcriptional control of a gene specifying a 56,000-Da protein in Ehrlich Ascites Tumor Cells. Virology 142: 389–397, 1985Google Scholar
  11. Engel, D., Snoody, J., Toniato, E., and Lengyel, P. Interferons as gene activators: close linkage of two interferon-activatable murine genes. Virology 166: 24–29, 1988Google Scholar
  12. Gaczynski, M., Briggs, J. A., Wedrychowski, A., Olinski, R., Uskokovic, M., Lian, J. B., Stein, G. S., and Briggs, R. C. cisdiamminedichloroplatinum(II) cross-linking of the human myeloid cell nuclear differentiation antigen to DNA in HL-60 cells following 1,25-dihydroxyvitamin D3-induced monocyte differentiation. Cancer Res 50: 1183–1188, 1990Google Scholar
  13. Goldberger, A., Hnilica, L. S., Casey, S. B., and Briggs, R. C. Properties of a nuclear protein marker of human myeloid cell differentiation. J Biol Chem 261: 4726–4731, 1986Google Scholar
  14. Goldberger, A., Brewer, G., Hnilica, L. S., and Briggs, R. C. Non-histone protein antigen profiles of five leukemic cell lines reflect the extent of myeloid cell differentiation. Blood 63: 701–710, 1984Google Scholar
  15. Gunning, P., Pointe, P., Okayama, H., Engel, J., Blau, H., and Kedes, L. Isolation and characterization of full-length cDNA clones for human α-, β-, and λ-actin mRNAs: skeletal but not cytoplasmic actins have an amino terminal cysteine that is subsequently removed. Mol Cell Biol 3: 787–795, 1983Google Scholar
  16. Kingsmore, S. F., Watson, M. L., Howard, T. A., and Seldin, M. F. A. 6000 kb segment of chromosome 1 is conserved in human and mouse. EMBO J 8: 4073–4080, 1989Google Scholar
  17. Opdenakker, G., Snoddy, J., Choubey, D., Toniato, E., Pravtcheva, D. D., Seldin, M. F., Ruddle, M. F., and Lengyel, P. Interferons as gene activators: a cluster of six interferon-activatable genes is linked to the erythroid α-spectrin locus on murine chromasome 1. Virology 171: 568–578, 1989Google Scholar
  18. Samanta, H., Engel, D. A., Chao, H. M., Thakur, A., Garcia-Blanco, M. A., and Lengyel, P. Interferons as gene activators. Cloning of the 5′ terminus and the control segment of an interferon activated gene. J Biol Chem 261: 11849–11858, 1986Google Scholar
  19. Tannenbaum, C. S., Major, J., Ohmori, Y., and Hamilton, T. A. A lipopolysaccharide-inducible macrophage gene (D3) is a new member of an interferon-inducible gene cluster and is selectively expressed in mononuclear phagocytes. J Leukoc Biol 53: 563–568, 1993Google Scholar
  20. Trapani, J. A., Browne, K. A., Dawson, M. J., Ramsay, R. G., Eddy, R. L., Shows, T. B., White, P. C., and Dupont, B. A novel gene constitutively expressed in human lymphoid cells is inducible with interferon-λ in myeloid cells. Immunogenetics 36: 369–376, 1992Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Michelle J. Dawson
    • 1
  • Joseph A. Trapani
    • 1
  • Robert C. Briggs
    • 2
  • Jillian K. Nicholl
    • 3
  • Grant R. Sutherland
    • 3
  • Elizabeth Baker
    • 3
  1. 1.Cellular Cytotoxicity Laboratory, The Austin Research Institute, Kronheimer BuildingAustin HospitalHeidelbergAustralia
  2. 2.Department of PathologyVanderbilt UniversityNashvilleUSA
  3. 3.Centre for Medical Genetics, Department of CytogeneticsWomen's and Children's HospitalAdelaideAustralia

Personalised recommendations