Visual evoked potentials after photostress in newly diagnosed insulin-dependent diabetes patients

  • Vincenzo Parisi
  • Luigi Uccioli
  • Giovanna Monticone
  • Leoluca Parisi
  • Laura Durola
  • Claudio Pernini
  • Riccardo Neuschuler
  • Guido Menzinger
  • Massimo G. Bucci
Clinical Investigations


•Background: The study was performed in order to ascertain whether electrophysiological abnormalities in visual function exist in newly diagnosed diabetic patients. •Methods: Visual evoked potentials (VEPs) were assessed under basal conditions and after photostress in normal control subjects and in newly diagnosed diabetic patients free of any fluorescein angiography signs of retinopathy. • Results: In basal conditions VEP P100 latency was significantly increased in the diabetic patients compared to controls (P<0.01), while N75-P100 amplitude was similar in both groups. After photostress N75-P100 amplitude (mean percentage decrement) was significantly higher in diabetic patients (P<0.01), while P100 latency (mean increment) and recovery time (time at which VEPs were superimposable on basal condition) were similar in the two groups. • Conclusions: The impaired basal VEPs suggest an early involvement of conduction in the optic nerve. In contrast, the preserved recovery time after photostress indicates that a short duration of disease does not induce physiopathological changes in macular function.


Diabetic Patient Optic Nerve Recovery Time Fluorescein Angiography P100 Latency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Pozzessere G, Rizzo PA, Valle E, Mollica MA, Sanarelli L, Morano S, Pietravalle P, Di Mario U, Morocutti C (1989) A longitudinal study of multimodal evoked potentials in diabetes mellitus. Diabetes Res 10: 17–20Google Scholar
  2. 2.
    Algan M, Ziegler O, Gehin P, Got I, Raspiller A, Weber M, Genton P, Saudax E, Drouin P (1989) Visual evoked potentials in diabetic patients. Diabetes Care 12:227–229Google Scholar
  3. 3.
    Cirillo D, Gonfiantini E, De Grandis D, Bongiovanni L, Robert JJ, Pinelli L (1984) Visual evoked potentials in diabetic children and adolescents. Diabetes Care 7: 273–275Google Scholar
  4. 4.
    Collier A, Mitchell JD (1985) Visual evoked potentials and contrast sensitivity function in diabetic retinopathy. Br Med J 291:248Google Scholar
  5. 5.
    Comi G, Martinelli V, Galardi G, Medaglini S, Poggi A, Beccaria L, Meschi F, Flores D'Arcais A (1986) Visual evoked potentials in diabetic teenagers: influence of metabolic control and relationship with peripheral neuropathy. Methods Pediatr Syst Ophthalmol 9:85–87Google Scholar
  6. 6.
    Comi G, Martinelli V, Galardi G, Medaglini S, Beccaria L, Meschi F, Rosti L, Bressani N, Chiumello G (1987) Evaluation of central nervous conduction by visual evoked potentials in insulin-dependent diabetic children. Metabolic and clinical correlation. Acta Diabetol Lat 24: 157–162Google Scholar
  7. 7.
    Puvanendran K, Davethasan G, Wong PK (1983) Visual evoked responses in diabetes. J Neurol Neurosurg Psychiatry 46:543–547Google Scholar
  8. 8.
    Sartucci F, Tognoni G, Guerrini V, Calisti L, Federico G, Saggese G, Murri L (1993) Combined use of pattern electroretinograms and visual evoked potentials in evaluation of early visual system involvement in type I diabetic children and adolescents. It J Clin Neurophysiol 2:10–24Google Scholar
  9. 9.
    Uccioli L, Monticone G, Parisi V, Parisi L, Bucci MG, Menzinger G (1993) Potenziali evocati visivi in soggetti diabetici insulino-dipendenti con e senza retinopatia. Giorn Ital Diab 13:259–264Google Scholar
  10. 10.
    Parisi V, Uccioli L, Monticone G, Parisi L, Menzinger G, Bucci MG (1994) Visual evoked potentials after photostress in insulin-dependent diabetic patients with or without retinopathy. Graefe's Arch Clin Exp Ophthalmol 232:193–198Google Scholar
  11. 11.
    Monticone G, Parisi V, Uccioli L, Durola L, Neuschuler R, Bucci MG, Menzinger G (1994) Early impaired macular function in IDDM patients without retinopathy. Diabetes 43 [Suppl 1]: 209AGoogle Scholar
  12. 12.
    Klein BEK, Davis MD, Segal P (1984) Diabetic retinopathy: assessment of severity and progression. Ophthalmology 91:10–17Google Scholar
  13. 13.
    Rizzo P, Carboni M, Passaro R, Parisi V, Del Giudice R, Rizzo A, Terrana P (1988) Potenziali evocati visivi da checkerboard pattern reversal: dati normativi. Riv Med Aeronaut Spaz 2:99–105Google Scholar
  14. 14.
    Arden GB, Hamilton AMP, WilsonHolt J, Ryan S, Yudkin JS, Kurtz A (1986) Pattern electroretinograms become abnormal in the preproliferative stage: possible use as a screening test. Br J Ophthalmol 70:330–335Google Scholar
  15. 15.
    Boschi MC, Frosini R, Menicucci R, Sodi A (1989) The influence of early diabetes on pattern electroretinogram. Doc Ophthalmol 71:369–374Google Scholar
  16. 16.
    Falsini B, Porciatti V, Scalia G, Caputo S, Minnella A, Di Leo MAS, Ghirlanda G (1989) Steady-state electroretinogram in insulin-dependent diabetics with no or minimal retinopathy. Doc Ophthalmol 73:193–200Google Scholar
  17. 17.
    Martinelli V, Merenda M, Natali-Sora MG, Meschi F, Beccaria L, Comi G (1987) Correlation between pattern electroretinography and visual evoked potentials in diabetes. Electroencephalogr Clin Neurophysiol 66 [Suppl 64]Google Scholar
  18. 18.
    Porciatti V, von Berger GP (1983) Pattern electroretinogram and visual evoked potentials in optic nerve disease: early diagnosis and prognosis. Doc Ophthalmol Proc Ser 40:117–126Google Scholar
  19. 19.
    Trick GL, Burde RM, Gordon MO, Kilo C, Santiago JV (1988) Retinocortical conduction time in diabetics with abnormal pattern reversal electroretinogram and visual evoked potentials. Doc Ophthalmol 70:19–28Google Scholar
  20. 20.
    Martinelli V, Filippi M, Meschi F, Pozza G, Canal N, Comi GC (1991) Electrophysiological study of optic pathways in insulin dependent diabetes mellitus. Clin Vision Sci 6:437–443Google Scholar
  21. 21.
    Parisi V, Bucci MG (1992) Visual evoked potentials after photostress in patients with primary open-angle glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 33:436–442Google Scholar
  22. 22.
    Lovasik JV (1983) An electrophysiological investigation of the macular photostress test. Invest Ophthalmol Vis Sci 24:437–441Google Scholar
  23. 23.
    Franchi A, Magni R, Lodigiani R, Cordella M (1987) VEP pattern after photostress: an index of macular function. Graefe's Archive Clin Exp Ophthalmol 225: 291–294Google Scholar
  24. 24.
    Bianchini E, Franchi A, Manni R, Villani LG, Cordella M, Botta GC (1987) Carotid occlusive disease: an electrophysiological macular investigation. J Cardiovasc Surg 28:524–527Google Scholar
  25. 25.
    Bucci MG, Parisi V, Giannini R, Rossini PM (1991) Recordings of visual evoked potentials after photostress in artificially increased intraocular pressure. Clin Vision Sci 6:431–436Google Scholar
  26. 26.
    Ghirlanda G, Di Leo MAS, Caputo S, Falsini B, Porciatti V, Marietti G, Greco AV (1991) Detection of inner retina dysfunction by steady-state focal electroretinogram pattern and flicker in early IDDM. Diabetes 9:1122–1127Google Scholar

Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Vincenzo Parisi
    • 1
    • 2
  • Luigi Uccioli
    • 3
  • Giovanna Monticone
    • 3
  • Leoluca Parisi
    • 4
  • Laura Durola
    • 3
  • Claudio Pernini
    • 2
  • Riccardo Neuschuler
    • 2
  • Guido Menzinger
    • 3
  • Massimo G. Bucci
    • 1
  1. 1.Cattedra di Clinica Oculistica Universitá di Roma Tor VergataComplesso Integrato ColumbusRomeItaly
  2. 2.Divisione OculisticaOspedale FatebenefratelliRomeItaly
  3. 3.Cattedra di EndocrinologiaUniversitá di Roma Tor Vergata -Complesso Integrato ColumbusRomeItaly
  4. 4.II Clinica NeurologiaUniversity di Roma La SapienzaRomeItaly

Personalised recommendations