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Immunogenetics

, Volume 35, Issue 3, pp 214–216 | Cite as

Localization of the gene cluster encoding the A, B, and C chains of human C1q to 1p34.1–1p36.3

  • Grant C. Sellar
  • David Cockburn
  • Kenneth B. M. Reid
Brief communication

Keywords

Gene Cluster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Boyd, Y., Cockburn, D., Holt, S., Munro, E., van Ommen, G. B., Gillard, B., Affara, N., Ferguson-Smith, M., and Craig, I.: Mapping of 12 translocation breakpoints in the Xp21 region with respect to the locus for Duchenne muscular dystrophy. Cytogenet Cell Genet 48: 28–34, 1988Google Scholar
  2. Brodsky-Doyle, B., Leonard, K. R., and Reid, K. B. M.: Circular-dichroism and electron-microscopy studies of human subcomponent C1q before and after limited proteolysis by pepsin. Biochem J 9: 279–286, 1976Google Scholar
  3. Goundis, D.: Structure, biosynthesis and cDNA cloning studies of properdin of the serum complement system. D. Phil. thesis, Oxford University, UK, 1988Google Scholar
  4. Goundis, D., Holt, S. M., Boyd, Y., and Reid, K. B. M.: Localization of the properdin structural locus to Xp11.23-Xp21.1. Genomics 5: 56–60, 1989Google Scholar
  5. Hedge, P. J., Sellar, G. C., Reid, K. B. M., and Solomon, E.: Assignment of the A chain of C1q (C1QA) to the short arm of chromosome 1. Cytogenet Cell Genet 46: 627, 1987Google Scholar
  6. Knobel, H. R., Villiger, W., and Isliker, H.: Chemical analysis and electron microscopy studies of human C1q prepared by different methods. Eur J Immunol 5: 78–81, 1975Google Scholar
  7. Lindenbaum, R. H., Clarke, G., Patel, C., Moncrieff, M., and Hughes, J. T.: Muscular dystrophy in an X; 1 translocation female suggests that Duchenne locus is on X chromosome short arm. J Med Genet 16: 389–392, 1979Google Scholar
  8. Nolan, K. F., Schwaeble, W., Kaluz, S., Dierich, M. P., and Reid, K. B. M.: Molecular cloning of a cDNA coding for proferdin, a positive regulator of the alternative pathway of human complement. Eur J Immunol 21: 771–776, 1991Google Scholar
  9. Reid, K. B. M.: Proteins involved in the activation and control of the two pathways of human complement. Biochem Soc Trans 11: 1–12, 1983Google Scholar
  10. Reid, K. B. M.: Molecular cloning and characterization of the complementary DNA and gene coding for the B-chain of subcomponent C1q of the human complement system. Biochem J 231: 729–735, 1985Google Scholar
  11. Reid, K. B. M. and Porter, R. R.: Subunit composition and structure of subcomponent C1q of the first component of human complement. Biochem J 155: 19–23, 1976Google Scholar
  12. Sellar, G. C., Blake, D. J., and Reid, K. B. M.: Characterization and organization of the genes encoding the A-,B-, and C-chains of human complement subcomponent C1q: The complete derived amino acid sequence of human C1q. Biochem J 274: 481–490, 1991Google Scholar
  13. Sellar, G. C., Goundis, D., McAdam, R. A., Solomon, E., and Reid, K. B. M.: Cloning and chromosomal localisation of the A-chain of human C1q: identification of molecular defect in a C1q-deficient patient. Complement Inflamm 4: 225, 1987Google Scholar
  14. Solomon, E., Skok, J., Griffin, J., andReid, K. B. M.: Human C1q B chain (C1QB) is on chromosome 1p. Cytogenet Cell Genet 40: 749, 1985Google Scholar

Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Grant C. Sellar
    • 1
  • David Cockburn
    • 2
  • Kenneth B. M. Reid
    • 1
  1. 1.MRC Immunochemistry UnitUniversity of OxfordOxfordUK
  2. 2.Genetics Laboratory, Department of BiochemistryUniversity of OxfordOxfordUK

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