The clinical investigator

, Volume 70, Issue 3–4, pp 352–367 | Cite as

Uptake of tobacco smoke constituents on exposure to environmental tobacco smoke (ETS)

  • G. Scherer
  • C. Conze
  • A. R. Tricker
  • F. Adlkofer
Original Article

Summary

For the purpose of risk evaluation, passive smoking is frequently regarded as low-dose cigarette smoking. However, since the physical, chemical and biological properties of mainstream smoke (MS), which is inhaled by the smoker and environmental tobacco smoke (ETS), which is breathed by the passive smoker are quite different, risk extrapolation from active smoking to passive smoking is of doubtful value. In a series of experimental exposure studies we compared the uptake of tobacco smoke constituents by active and passive smoking. The results show that biomarkers which were found to be elevated after experimental ETS exposure, such as nicotine and cotinine in plasma and urine as well as thioethers in urine, indicate gas-phase exposure in passive smokers, but particle-phase exposure in active smokers. Biomarkers which should indicate the uptake of particle-bound, genotoxic substances with ETS, such as urinary mutagenicity, metabolites of polycyclic aromatic hydrocarbons (PAH) and DNA adducts, were not found to be elevated even after extremely high ETS exposure. From these results we conclude that a risk evaluation for passive smoking on the basis of dosimetric data is currently not possible.

Key words

Environmental tobacco smoke (ETS) Passive smoking Smoking Biomonitoring Gas phase Particle phase Genotoxic substances 

Abbreviations

1-ABP

4-aminobiphenyl

BaA

benzo(a)anth-racene

BaP

benzo(e)pyrene

BE

butanol extraction

BeP

benzo(e)pyrene

CO

carbon monoxide

COHb

carboxyhae-moglobin

DABS

DNA binding substances

DRZ

diagonal radioactive zone

ETS

environmental tobacco smoke

GC

gas chromatography

GC/MS

gas chromatography coupled to mass spectrometry

HPLC

high performance liquid chromatography

HPMA

3-hydroxypropylmercapturic acid

MS

mainstream smoke

NNK

4-(N-nitrosomethylamino)-1-(3-pyridyl)-1-butanone

NNN

N-nitrosonornicotine

NOxa

nitrogen oxides (NO/NO2)

PAH

polycyclic aromatic hydrocarbons

PhIP

2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine

P1

nuclease P1

RSP

respirable particles

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • G. Scherer
    • 1
  • C. Conze
    • 1
  • A. R. Tricker
    • 1
  • F. Adlkofer
    • 1
  1. 1.Analytisch-biologisches Forschungslabor Prof. AdlkoferMünchen 2Germany

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