Journal of Molecular Evolution

, Volume 35, Issue 2, pp 147–155

Phylogenetic analysis of the thiolase family. Implications for the evolutionary origin of peroxisomes

  • J. C. Igual
  • C. González-Bosch
  • J. Dopazo
  • J. E. Pérez-Ortín
Article

Summary

The thiolase family is a widespread group of proteins present in prokaryotes and three cellular compartments of eukaryotes. This fact makes this family interesting in order to study the evolutionary process of eukaryotes. Using the sequence of peroxisomal thiolase from Saccharomyces cerevisiae recently obtained by us and the other known thiolase sequences, a phylogenetic analysis has been carried out. It shows that all these proteins derived from a primitive enzyme, present in the common ancestor of eubacteria and eukaryotes, which evolved into different specialized thiolases confined to various cell compartments. The evolutionary tree obtained is compatible with the endosymbiotic theory for the origin of peroxisomes.

Key words

Thiolase Peroxisome evolution Bootstrap analysis Saccharomyces cerevisiae 

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Copyright information

© Springer-Verlag New York Inc 1992

Authors and Affiliations

  • J. C. Igual
    • 1
  • C. González-Bosch
    • 1
  • J. Dopazo
    • 2
  • J. E. Pérez-Ortín
    • 1
  1. 1.Departamento de Bioquímica y Biología MolecularUniversitat de ValènciaSpain
  2. 2.I.N.I.A.-Sanidad AnimalMadridSpain

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