Histamine H3 receptor-mediated inhibition of serotonin release in the rat brain cortex

  • Eberhard Schlicker
  • Roland Betz
  • Manfred Göthert
Short communication


Rat brain cortex slices preincubated with 3H-serotonin were superfused with physiological salt solution (containing citalopram, an inhibitor of serotonin uptake) and the effect of histamine on the electrically (3 Hz) evoked 3H overflow was studied. Histamine decreased the evoked overflow in a concentration-dependent manner. The inhibitory effect of histamine was antagonized by impromidine and burimamide, but was not affected by pheniramine, ranitidine, metitepine and phentolamine. Given alone, impromidine facilitated the evoked overflow, whereas burimamide, pheniramine and ranitidine had no effect. The results suggest that histamine inhibits serotonin release in the rat brain cortex via histamine H3 receptors, which may be located presynaptically.

Key words

Rat brain cortex Serotonin release Presynaptic H3 Receptors Impromidine Burimamide 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Eberhard Schlicker
    • 1
  • Roland Betz
    • 1
  • Manfred Göthert
    • 1
  1. 1.Institut für Pharmakologie und Toxikologie der Rheinischen Friedrich-Wilhelms-Universität BonnBonn 1Federal Republic of Germany

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