Current status of HLA matching in renal transplantation
- 59 Downloads
The impact of HLA compatibility on the success rate of kidney transplants was studied in over 80,000 recipients of primary transplants. The transplants were done from 1982 to 1991 at over 300 transplant centers in 43 countries. The results show that matching the HLA chromosomes in related donor transplants has a striking influence. It is also important that matching for individual HLA antigens in cadaver transplants provides a highly significant improvement in graft survival (P<0.0001). After 5 years, matched grafts have a survival rate approximately 20% higher than completely mismatched grafts. The matching effect is particularly strong in presensitized and second graft recipients. There is now direct evidence that even if it is necessary to transport well-matched kidneys a long way, they have a significantly higher success rate than locally transplanted poorly matched kidneys. New data based on molecular technology show that the precise identification of HLA-DR antigens by DNA typing further improves the success rate of HLA-matched transplants.
Key wordsHLA matching Renal transplantation DNA typing
restriction fragment length polymorphism
Unable to display preview. Download preview PDF.
- 5.Wujciak T, Opelz G (to be published) Computer analysis of cadaver kidney allocation procedures. Transplantation.Google Scholar
- 6.Olerup O, Zetterquist H (to be published) HLA-DRB1 typing by PCR amplification with sequence-specific primers (PCR-SSP): postamplification processing in less than 20 min. In: Tsuji et al. (eds) HLA 1991. Oxford University Press, Oxford.Google Scholar