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The clinical investigator

, Volume 70, Issue 9, pp 728–734 | Cite as

Failure to detect any effect of amalgam restorations on peripheral blood lymphocyte populations

  • M. Wilhelm
  • P. Dünninger
  • R. Rüppel
  • H. -P. Tony
  • K. Wilms
  • B. Klaiber
Original Article

Summary

Dental amalgam has been considered to have adverse side effects on the immune system. Reports have been contradictory, indicating both an increase and a decrease in peripheral blood lymphocyte counts associated with amalgam restorations. We investigated two groups of patients, one of which was treated with amalgam restorations for the first time. In the other group, all existing amalgam fillings were removed. Prior to and after treatment, we determined the absolute and relative numbers of granulocytes, lymphocytes, monocytes, T cells, B cells, cytotoxic T cells, helper T cells and natural killer cells. In addition, functional investigations of T cells were performed. We failed to find any effect of amalgam restorations on the immune system in terms of the parameters investigated.

Key words

Amalgam Lymphocytes Immune system 

Abbreviations

CD

cluster of differentiation

cpm

counts per minute

FACS

fluorescence-activated cell analysis

PHA

phytohaemagglutinin

FITC

fluorescein isothiocyanate

Ig

Immunoglobulin

μCi

microCurie

NK cell

natural killer cell

PE

phycoerythrin

Hb

haemoglobin

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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • M. Wilhelm
    • 2
  • P. Dünninger
    • 1
  • R. Rüppel
    • 2
  • H. -P. Tony
    • 2
  • K. Wilms
    • 2
  • B. Klaiber
    • 1
  1. 1.Poliklinik für Zahnerhaltung und ParadontologieUniversität WürzburgGermany
  2. 2.Medizinische Poliklinik der UniversitätWürzburgGermany

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