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Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 343, Issue 4, pp 427–430 | Cite as

Nicotine reverses hemorrhagic shock in rats

  • Salvatore Guarini
  • Simonetta Tagliavini
  • Carla Bazzani
  • Alfio Bertolini
  • William Ferrari
Short communication

Summary

Cholinergic mechanisms are currently thought to play an essential role in blood pressure homeostasis. Here we show that, in urethane-anaesthetized rats bled to severe hemorrhagic shock, the i. v. administration of nicotine 0.2–50 μg/kg causes a prompt, sustained and dose-dependent improvement in cardiovascular and respiratory functions, the animals' survival rate being significantly higher than that of animals treated with saline. These effects are prevented by bilateral cervical vagotomy and by concurrent local anaesthesia of the carotid bodies, which suggests that stimulation of visceral afferents is the main mechanism of action of nicotine in hemorrhagic shock.

Key words

Hypovolemic shock Hemorrhage Nicotine Resuscitation 

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Copyright information

© Springer-Verlag 1991

Authors and Affiliations

  • Salvatore Guarini
    • 1
  • Simonetta Tagliavini
    • 1
  • Carla Bazzani
    • 1
  • Alfio Bertolini
    • 1
  • William Ferrari
    • 1
  1. 1.Institute of PharmacologyUniversity of ModenaModenaItaly

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