Psychopharmacology

, Volume 92, Issue 2, pp 262–264 | Cite as

Effects of pimozide on sucrose consumption and preference

  • A. Towell
  • R. Muscat
  • P. Willner
Original Investigations

Abstract

The effects of pimozide on sucrose intake were examined, in a two-bottle preference test (sucrose versus water), and in single-bottle tests at five different sucrose concentrations. In the two-bottle test, pimozide dose dependently decreased sucrose intake but increased water intake. In the single-bottle test pimozide decreased sucrose intake at low concentrations but had no effect at high concentrations. The results support a role for dopamine in mediating the rewarding effect of sucrose.

Key words

Sucrose preference Two-bottle test Pimozide Dopamine 

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • A. Towell
    • 1
  • R. Muscat
    • 1
  • P. Willner
    • 1
  1. 1.Psychology DepartmentCity of London PolytechnicLondonUK

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