, Volume 94, Issue 2, pp 147–160 | Cite as

Is the forced swimming test a suitable model for revealing antidepressant activity?

  • Franco Borsini
  • Alberto Meli


The forced swimming test is reviewed. This test appears to be suitable for detecting antidepressant activity in rats but not in mice. Difference in experimental procedure may account for the different sensitivity to drugs of the two animal species.

Key words

Forced swimming test Depression Validity 


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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Franco Borsini
    • 1
  • Alberto Meli
    • 1
  1. 1.Research Department‘A. Menarini’ PharmaceuticalsFirenzeItaly

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