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Psychopharmacology

, Volume 92, Issue 4, pp 505–507 | Cite as

Human pharmacology of 1S and 1R enantiomers of delta-3-tetrahydrocannabinol

  • L. E. Hollister
  • H. K. Gillespie
  • R. Mechoulam
  • M. Srebnik
Original Investigations

Abstract

Two enantiomers (1S and 1R) of delta-3-tetrahydrocannabinol were assayed in man for psychoactivity. The 1S enantiomer had definite psychic actions, qualitatively similar to those of delta-1-tetrahydrocannabinol, but quantitatively less potent (1:3 to 1:6). Adding the two enantiomers together did not increase the effect, confirming that activity was solely in the one enantiomer and that there was no interaction between them.

Key words

Enantiomers 1S and 1R Delta-3-tetrahydrocannabinol Psychoactivity 

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References

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Copyright information

© Springer-Verlag 1987

Authors and Affiliations

  • L. E. Hollister
    • 1
  • H. K. Gillespie
    • 1
  • R. Mechoulam
    • 2
  • M. Srebnik
    • 2
  1. 1.Veterans Administration Medical CenterPalo AltoUSA
  2. 2.Medical FacultyHebrew University of JerusalemIsrael

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