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Psychopharmacology

, Volume 94, Issue 3, pp 433–434 | Cite as

Effects of chlordiazepoxide, pentobarbital, buspirone, chlorpromazine, and morphine in the stretched attend posture (SAP) test

  • Gerald T. Pollard
  • James L. Howard
Rapid Communications

Abstract

The stretched attend posture (SAP) in the mouse is an investigatory forward elongation of the body in a novel environment. In a previous study, the anxiolytics diazepam, clobazam, and phenobarbital reduced SAP, and low doses of the non-anxiolytics imipramine and chlorpromazine were ineffective, results which prompted the investigator to propose the SAP test as a screening method for anxiolytics. However, diazepam and clobazam also increased immobility. In the present study, the anxiolytics chlordiazepoxide, pentobarbital, and buspirone and behaviorally active doses of the non-anxiolytics chlorpromazine and morphine reduced SAP and tended to increase immobility. We concluded that therapeutic-class specificity has not been demonstrated for the SAP test.

Key words

Stretched attend posture Anxiolytics Chlordiazepoxide Pentobarbital Buspirone Chlorpromazine Morphine Animal model Mouse 

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Copyright information

© Springer-Verlag 1988

Authors and Affiliations

  • Gerald T. Pollard
    • 1
  • James L. Howard
    • 1
  1. 1.Department of PharmacologyBurroughs Wellcome Co.Research Triangle ParkUSA

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