Psychopharmacology

, Volume 89, Issue 3, pp 378–381 | Cite as

The effect of pramiracetam (CI-879) on the acquisition of a radial arm maze task

  • C. L. Murray
  • H. C. Fibiger
Original Investigations

Abstract

The effect of the nootropic drug pramiracetam (CI-879) on acquisition of a radial arm maze task was examined in the rat. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food. This procedure permitted a distinction between working memory (short-term) and reference memory (long-term). Both doses of pramiracetam significantly improved performance in the reference memory component of the task, but did not significantly affect the working memory component. These data indicate that pramiracetam can enhance some aspects of spatial learning and memory in the rat.

Key words

Alzheimer's disease Cholinergic systems Nootropic Pramiracetam Radial-arm maze Working memory Reference memory 

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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • C. L. Murray
    • 1
  • H. C. Fibiger
    • 1
  1. 1.Division of Neurological Sciences, Department of PsychiatryUniversity of British ColumbiaVancouverCanada

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