, Volume 89, Issue 3, pp 378–381 | Cite as

The effect of pramiracetam (CI-879) on the acquisition of a radial arm maze task

  • C. L. Murray
  • H. C. Fibiger
Original Investigations


The effect of the nootropic drug pramiracetam (CI-879) on acquisition of a radial arm maze task was examined in the rat. Two doses of pramiracetam (7.5 mg/kg and 15 mg/kg) were administered daily prior to testing for 7 weeks in a 16-arm radial maze in which nine arms were baited with food. This procedure permitted a distinction between working memory (short-term) and reference memory (long-term). Both doses of pramiracetam significantly improved performance in the reference memory component of the task, but did not significantly affect the working memory component. These data indicate that pramiracetam can enhance some aspects of spatial learning and memory in the rat.

Key words

Alzheimer's disease Cholinergic systems Nootropic Pramiracetam Radial-arm maze Working memory Reference memory 


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  1. Bartus RT (1982) Effects of cholinergic agents on learning and memory in animal models of aging. In: Corkin S, Davis KL, Growdon JH, Usdin E, Wurtman RJ (eds) Alzheimer's disease: A report of progress in research. Raven Press, New York, pp 271–280Google Scholar
  2. Bartus RT, Dean RL, Beer B, Lippa AS (1982) The cholinergic hypothesis of geriatric memory dysfunction: A critical review. Science 217:408–414Google Scholar
  3. Blessed G, Tomlinson BE, Roth M (1968) The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects. Br J Psychiatry 114:797–811Google Scholar
  4. Branconnier RJ, Cole JO, Dessain EC, Spera KF, Ghazvinian S, DeVitt D (1983) The therapeutic efficacy of pramiracetam in Alzheimer's disease: Preliminary observations. Psychopharmacol Bull 19:726–730Google Scholar
  5. Buresova O, Bures J (1982) Radial maze as a tool for assessing the effect of drugs on the working memory of rats. Psychopharmacology 77:268–271Google Scholar
  6. Corkin S, Davis KL, Growdon JH, Usdin E, Wurtman RJ (1982) Alzheimer's disease: A report of progress in research. Raven Press, New YorkGoogle Scholar
  7. de Toledo-Morrell L, Morrell F, Fleming S, Cohen MS (1984) Pentoxifylline reverses age-related deficits in spatial memory. Behav Neural Biol 42:1–8Google Scholar
  8. Giurgea CE, Greindl MG, Preat S (1983) Nootropic drugs and aging. Acta Psychiatr Belg 83:349–358Google Scholar
  9. Giurgea C, Salama M (1977) Nootropic drugs. Prog Neuropsychopharmacol 1:235–247Google Scholar
  10. Goodnick P, Gershon S, Salzman C (1984) Dementia and memory loss in the elderly. In: Salzman C (ed) Clinical geriatric psychopharmacology. McGraw-Hill, pp 171–198Google Scholar
  11. Ingram DK, London ED, Goodrick CL (1981) Age and neurochemical correlates of radial maze performance in rats. Neurobiol Aging 2:41–47Google Scholar
  12. Murray CL, Fibiger HC (1985) Learning and memory deficits after lesions of the nucleus basalis magnocellularis: Reversal by physostigmine. Neuroscience 14:1025–1032Google Scholar
  13. Olton DS, Collison C (1979) Intramaze cues and “odor trails” fail to direct choice behavior on an elevated maze. Animal Learn Behav 7:221–223Google Scholar
  14. Olton DS, Papas BC (1979) Spatial memory and hippocampal function. Neuropsychologia 17:669–682Google Scholar
  15. Olton DS, Samuelson RJ (1976) Remembrance of place past: Spatial memory in rats. J Exp Psychol 2:97–116Google Scholar
  16. Poschel BPH, Marriott JG, Gluckman MI (1983) Pharmacology of the cognition activator pramiracetam (CI-879). Drugs Exptl Clin Res 12:853–871Google Scholar
  17. Poschel BPH, Ho PM, Ninteman FW, Callahan MJ (1986) Pharmacologic therapeutic window of pramiracetam demonstrated in behavior, EEG, and single neuron firing rates. Experientia (in press)Google Scholar
  18. Pugsley TA, Poschel BPH, Downs DA, Shih Y, Gluckman MI (1983) Some pharmacological and neurochemical properties of a new cognition activator agent, pramiracetam (CI-879) Psychopharmacol Bull 19:721–726Google Scholar
  19. Rogers JD, Brogan D, Mirra SS (1985) The nucleus basalis of Meynert in neurological disease: A quantitative morphological study. Ann Neurol 17:163–170Google Scholar
  20. Terry RD, Katzman R (1983) Senile dementia of the Alzheimer type. Ann Neurol 14:497–506Google Scholar
  21. Walker JA, Olton DS (1984) Fimbria-fornix lesions impair spatial working memory but not cognitive mapping. Behav Neurosci 98:226–242Google Scholar

Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • C. L. Murray
    • 1
  • H. C. Fibiger
    • 1
  1. 1.Division of Neurological Sciences, Department of PsychiatryUniversity of British ColumbiaVancouverCanada

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