, Volume 90, Issue 4, pp 468–470

Effects of smoking on haloperidol and reduced haloperidol plasma concentrations and haloperidol clearance

  • Michael W. Jann
  • Stephen R. Saklad
  • Larry Ereshefsky
  • Ann L. Richards
  • Charles A. Harrington
  • Chester M. Davis
Original Investigations


Plasma concentrations of haloperidol and its reduced metabolite (reduced haloperidol) were investigated in cigarette smokers (N=23) and nonsmokers (N=27). Steady-state plasma concentrations were obtained 12 h post bedtime dose. Haloperidol and reduced haloperidol concentrations were determined by RIA. Reduced haloperidol was separated by selective succinylation and liquid chromatography. Patients were clinically assessed with the Clinical Global Impression Scale (CGIS). Smokers had significantly lower haloperidol and reduced haloperidol plasma concentrations than nonsmokers (P<0.01, P<0.05). Clearance of haloperidol was significantly greater in smokers compared to nonsmokers (P=0.0052). CGIS assessments did not show significant differences between smokers and non-smokers. Plasma concentrations should be carefully monitored when patients either start or stop smoking.

Key words

Smoking Haloperidol Reduced haloperidol Plasma concentrations Clearance 


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Copyright information

© Springer-Verlag 1986

Authors and Affiliations

  • Michael W. Jann
    • 1
    • 2
    • 5
  • Stephen R. Saklad
    • 1
    • 2
    • 3
    • 6
  • Larry Ereshefsky
    • 1
    • 2
    • 3
    • 6
  • Ann L. Richards
    • 1
    • 6
  • Charles A. Harrington
    • 4
  • Chester M. Davis
    • 4
  1. 1.College of PharmacyThe University of Texas at AustinUSA
  2. 2.Department of PharmacologyThe University of Texas Health Science Center at San AntonioUSA
  3. 3.Department of PsychiatryThe University of Texas Health Science Center at San AntonioUSA
  4. 4.Department of PsychiatryUniversity of Texas Mental Science InstituteUSA
  5. 5.San Antonio State SchoolUSA
  6. 6.San Antonio State HospitalSan AntonioUSA
  7. 7.Clinical Pharmacy ProgramThe University of Texas Health Science CenterSan AntonioUSA

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