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Applied Microbiology and Biotechnology

, Volume 32, Issue 5, pp 511–517 | Cite as

Comparative studies on the fermentative production of lantibiotics by staphylococci

  • Thomas Hörner
  • Volker Ungermann
  • Hans Zähner
  • Hans-Peter Fiedler
  • Roland Utz
  • Roland Kellner
  • Günther Jung
Biotechnology

Summary

The production of the lanthionine-containing polypeptide antibiotics gallidermin from Staphylococcus gallinarum TÜ 3928 and pep 5 from S. epidermidis 5 is investigated with respect to regulation and stimulation of productivity by media components, optimization of both the media used and the fermentation process and is compared to the production of the lantibiotic epidermin from S. epidermidis TÜ 3298. Efficient methods for rapid quantification of lantibiotics, optimization of the media and a primary enrichment by adsorption chromatography are reported.

Keywords

Chromatography Fermentation Polypeptide Staphylococcus Efficient Method 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Thomas Hörner
    • 1
  • Volker Ungermann
    • 1
  • Hans Zähner
    • 1
  • Hans-Peter Fiedler
    • 1
  • Roland Utz
    • 2
  • Roland Kellner
    • 2
  • Günther Jung
    • 2
  1. 1.Lehrbereich Mikrobiologie/AntibiotikaUniversität TübingenTübingenFederal Republic of Germany
  2. 2.Institut für Organische ChemieUniversität TübingenTübingenFederal Republic of Germany

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