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Biotechnology Techniques

, Volume 10, Issue 5, pp 335–338 | Cite as

Preparation of optically pure chiral amines by lipase-catalyzed enantioselective hydrolysis of N-acyl-amines

  • Hauke Smidt
  • Andreas Fischer
  • Peter Fischer
  • Rolf D. Schmid
Article

Summary

A new and effective method using lipase from Candida antarctica (native or Novozym SP-435) for the preparation of enantiopure primary R-amines is reported. Hydrolysis of rac-N-acetyl-amines resulted in high conversion > 40% (168 hrs) and > 48% (> 240 hrs) and enantiomeric excesses (> 99% ee) for both the product and the remaining substrate.

Keywords

Hydrolysis Lipase Candida High Conversion Enantiomeric Excess 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman & Hall 1996

Authors and Affiliations

  • Hauke Smidt
    • 1
  • Andreas Fischer
    • 1
  • Peter Fischer
    • 2
  • Rolf D. Schmid
    • 1
  1. 1.Institute of Technical Biochemistry, University of StuttgartStuttgartGermany
  2. 2.Institute of Organic Chemistry and Isotope Research, University of StuttgartStuttgartGermany

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