Journal of Neuro-Oncology

, Volume 7, Issue 3, pp 249–254

Immunophenotypic profile of CNS lymphoma: A review of eighteen cases

  • R. Bashir
  • A. Freedman
  • N. Harris
  • K. Bain
  • L. Nadler
  • F. Hochberge


The cell surface antigenic phenotype of 18 cases of central nervous system (CNS) large-cell lymphoma (14 primary, four secondary) was examined by an immunoperoxidase technique using antibodies that identify B cell restricted and associated antigens. All cases were shown to be of B cell origin by virtue of the expression of monotypic immunoglobulin (Ig) (16 IgM, two IgG) and the pan B cell antigen B1 ( CD20). A panel of monoclonal antibodies directed against B cell restricted and associated activation antigens including B5, Blast-1, Blast-2 (CD23), BB1, interleukin 2 receptor (IL2R, CD25), T9 (transferrin receptor) and TNK-TAR (4F2) was used on 12 of the cases. The majority expressed T9 and TNK-TAR. Blast-1 was expressed by less than half the cases and Blast-2 and B5 by one of 12 cases each. This is in contrast to 10 non-CNS diffuse large cell lymphomas where B5 and Blast-1 were present on all cases. This study confirms previous observations that primary CNS large cell lymphomas are of B cell derivation. Moreover, the differences in expression of B cell activation antigens on CNS large cell lymphomas as compared to non-CNS lymphomas raise the possibility that a subset of neoplastic B cells may have unique tropism for the CNS.

Key words

lymphoma CNS lymphoma immunophenotype 


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Copyright information

© Kluwer Academic Publishers 1989

Authors and Affiliations

  • R. Bashir
    • 1
  • A. Freedman
    • 3
  • N. Harris
    • 2
  • K. Bain
    • 1
  • L. Nadler
    • 3
  • F. Hochberge
    • 1
  1. 1.Division of NeurologyUniversity of Nebraska Medical CenterUSA
  2. 2.Departments of Neurology and PathologyMassachusetts General HospitalUSA
  3. 3.Division of Tumor ImmunologyDana Farber Cancer InstituteUSA

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