Immunogenetics

, Volume 42, Issue 6, pp 501–530

Mouse T-cell receptor variable gene segment families

  • Bernhard Arden
  • Stephen P. Clark
  • Dieter Kabelitz
  • Tak W. Mak
Review

Abstract

All mouse T-cell receptor α/δ, β, and γ variable (Tcra/d, b-, and g-V) gene segments were aligned to compare the sequences with one another, to group them into subfamilies, and to derive a name which complies with the standard nomenclature. It was necessary to change the names of some V gene segments because they conflicted with those of other segments. The traditional classification into subfamilies was re-evaluated using a much larger pool of sequences. In the mouse, most V gene segments can be grouped into subfamilies of closely related genes with significantly less similarity between different subfamilies.

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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Bernhard Arden
    • 1
  • Stephen P. Clark
    • 2
  • Dieter Kabelitz
    • 1
  • Tak W. Mak
    • 3
  1. 1.Paul-Ehrlich-InstituteLangenGermany
  2. 2.Amgen CenterThousand OaksUSA
  3. 3.Amgen InstituteOntario Cancer InstituteToronto OntarioCanada

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