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Applied Microbiology and Biotechnology

, Volume 34, Issue 1, pp 87–90 | Cite as

Stimulatory effect of glycine betaine on l-lysine fermentation

  • Yoshio Kawahara
  • Yasuhiko Yoshihara
  • Shigeho Ikeda
  • Hiroe Yoshii
  • Yoshio Hirose
Applied Microbiology

Summary

The growth rate, sugar consumption rate, and production rate of an l-lysine producing Brevibacterium lactofermentum mutant were stimulated by addition of exogenous glycine betaine. Glycine betaine stimulated the growth rate especially in media of inhibitory osmotic stress, and the stimulation was independent of any specific solute. Therefore growth stimulation by glycine betaine was considered to be an osmoprotective effect. A strong enhancement of the sugar consumption rate and the l-lysine production rate was observed even with resting cells under osmotic stress as well as in a fermentation with growing cells. These data indicated that the osmoprotective effects of glycine betaine on l-lysine production can be independent of protein synthesis.

Keywords

Growth Rate Fermentation Protein Synthesis Production Rate Osmotic Stress 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag 1990

Authors and Affiliations

  • Yoshio Kawahara
    • 1
  • Yasuhiko Yoshihara
    • 1
  • Shigeho Ikeda
    • 1
  • Hiroe Yoshii
    • 1
  • Yoshio Hirose
    • 1
  1. 1.Technology and Engineering Center of Ajinomoto Co., Inc.Kawasaki-shiJapan

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