Naunyn-Schmiedeberg's Archives of Pharmacology

, Volume 353, Issue 5, pp 552–556 | Cite as

Effects of antimigraine drugs on retinal spreading depression

  • Meike Wiedemann
  • Vera M. Fernandes de Lima
  • Wolfgang Hanke
Original Article


It has been suggested that spreading depression may play a role in triggering classical migraine. In this study the retinal spreading depression was used as a pharmacological tool to test the neuronal effects of several common antimigraine drugs. As the chicken retina is void of any blood vessels the observed effects must be of pure neuronal origin. It is shown that propranolol, sumatriptan, methysergide, paracetamol and acetylsalicyclic acid decrease the propagation velocity of retinal spreading depression waves, accelerate the recovery of the optical and electrical signal and reduce the amplitude of the negative potential shift, concomitant with the spreading depression. Barbiturate increases the spreading velocity, and the amplitude of the potential shift. Ergotamine, clonidine, lisuride and iprazochrome have no significant influence on retinal spreading depression.

Key words

Retinal spreading depression Migraine Antimigraine drugs 


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Copyright information

© Springer-Verlag 1996

Authors and Affiliations

  • Meike Wiedemann
    • 1
  • Vera M. Fernandes de Lima
    • 2
  • Wolfgang Hanke
    • 1
  1. 1.Institut für Zoophysiologie 230 Universität HohenheimStuttgartGermany
  2. 2.Department of Biomedical EngineeringUNICAMPCampinas, SPBrazil

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