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Comparison of the effects of aminoguanidine and L-carnitine treatments on somatosensorial evoked potentials in alloxan-diabetic rats

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Abstract

The effects of aminoguanidine (AG) and L-carnitine (LC) on somatosensorial evoked potential (SEP) latency and neural levels of thiobarbituric acid reactive substances (TBARS), products of lipid peroxidation, were compared in alloxan-diabetic rats. AG and LC were given to diabetic rats starting from the 3rd week after the induction of diabetes and lasting for 4 weeks. SEP latency was measured by stimulating via caudal nerve and recording via cortex, once weekly during the treatments. Diabetes caused deficits in SEP (P < 0.05 vs non-diabetic control rats, respectively). AG and LC restored SEP latencies slightly but not significantly, with the exception of the prominent effect of AG at the first week and both treatments at the 4th week of the treatments (P < 0.05 vs untreated diabetic rats, respectively). Diabetes caused elevation in neural TBARS levels (P < 0.05 vs non-diabetic group), which was prevented by both AG and LC (P < 0.05 vs untreated diabetic rats, respectively). Weight and the glucose levels were not influenced by the treatments. Our results suggest that AG improves SEP latencies better than LC. Our results also suggest that the beneficial effects of both AG and LC on diabetic neuropathy are not associated with the regulation of glycemia, but these effects may be related in part with prevention of lipid peroxidation.

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Authors and Affiliations

  1. Department of Medical Pharmacology, Gülhane School of Medicine, 06018, Ankara, Turkey

    Oğuzhan Yildiz & Gönen Deniz

  2. Department of Endocrinology and Metabolism, Gülhane School of Medicine, 06018, Ankara, Turkey

    Metin Özata, Ahmet Çorakçi & Mehmet Ali Gündoğan

  3. Department of Neurology, Gülhane School of Medicine, 06018, Ankara, Turkey

    Abdullah Özkardeş & Muzaffer Yardim

  4. Department of Biochemistry, Gülhane School of Medicine, 06018, Ankara, Turkey

    Metin Yildirimkaya

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  1. Oğuzhan Yildiz
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  2. Metin Özata
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  3. Abdullah Özkardeş
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  4. Gönen Deniz
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Yildiz, O., Özata, M., Özkardeş, A. et al. Comparison of the effects of aminoguanidine and L-carnitine treatments on somatosensorial evoked potentials in alloxan-diabetic rats. Naunyn-Schmiedeberg's Arch Pharmacol 354, 526–531 (1996). https://doi.org/10.1007/BF00168446

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  • DOI: https://doi.org/10.1007/BF00168446

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