Journal of Neuro-Oncology

, Volume 11, Issue 1, pp 1–15 | Cite as

Medulloblastoma: tumor biological and clinical perspectives

  • Henry S. Friedman
  • W. fnJerry Oakes
  • Sandra H. Bigner
  • Carol J. Wikstrand
  • Darell D. Bigner


Medulloblastoma is the most common central nervous system malignancy of childhood, with approximately 350 new cases seen in the United States each year. Although the low incidence of this tumor, compared with adult neoplasms such as breast or colon carcinoma, has limited laboratory and clinical research, recent studies have greatly enhanced our understanding of the biology, phenotype, genotype, and therapy of medulloblastoma. Further efforts to integrate laboratory and clinical studies of this tumor may allow design of novel therapeutic approaches resulting in enhanced disease-free survival.

Key words

medulloblastoma c-myc neuronal glial chemotherapy radiotherapy 


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Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Henry S. Friedman
    • 1
    • 3
  • W. fnJerry Oakes
    • 1
    • 2
  • Sandra H. Bigner
    • 3
  • Carol J. Wikstrand
    • 3
  • Darell D. Bigner
    • 3
    • 4
  1. 1.Departments of PediatricsDuke University Medical CenterDurhamUSA
  2. 2.SurgeryDuke University Medical CenterDurhamUSA
  3. 3.Pathology Preuss Laboratory for Brain Tumor ResearchDuke University Medical CenterDurhamUSA
  4. 4.Preuss Laboratory for Brain Tumor ResearchDuke University Medical CenterDurhamUSA
  5. 5.Department of PediatricsDuke University Medical CenterDurhamUSA

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