Applied Microbiology and Biotechnology

, Volume 43, Issue 6, pp 985–988 | Cite as

Microbial production of specifically ring-13C-labelled 4-hydroxybenzoic acid

  • R. Müller
  • A. Wagener
  • K. Schmidt
  • E. Leistner
Original Paper


When transformed with a recombinant vector carrying the ubiC gene (encoding chorismate pyruvate-lyase, EC the triple mutant (Phe, Trp, Tyr) Klebsiella pneumoniae 62-1 excretes 4-hydroxybenzoic acid instead of chorismic acid. The recombinant strain can be used to produce in high yield specifically ring-labelled 4-hydroxybenzoic acid from isotopically labelled glucose.


Glucose Klebsiella Recombinant Strain Klebsiella Pneumoniae Microbial Production 
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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • R. Müller
    • 1
  • A. Wagener
    • 1
  • K. Schmidt
    • 1
  • E. Leistner
    • 1
  1. 1.Institut für Pharmazeutische BiologieRheinische Friedrich-Wilhelms-Universität BonnBonnGermany

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