, Volume 42, Issue 1, pp 59–62 | Cite as

Physical and genetic linkage of the genes encoding Ly-9 and CD48 on mouse and human chromosomes 1

  • Stephen F. Kingsmore
  • Carolyn A. Souryal
  • Mark L. Watson
  • Dhavalkumar D. Patel
  • Michael F. Seldin
Original Papers


By virtue of sequence similarity, the genes encoding CD2, CD48, CD58, and Ly-9 have been assigned to a distinct subset within the immunoglobulin superfamily. Previous gene mapping studies in human and mouse have suggested that CD2, CD48, and CD58 arose by gene duplication. Here we show the gene encoding Ly-9 to be located adjacent to CD48 and the Na,K-ATPase α2 subunit gene on human and mouse chromosome 1. The proximity in human and mouse genomes of the genes encoding CD2, CD58, and the Na,K-ATPase α1 subunit, and of the Ly-9, CD48, and the Na,K-ATPase α2 subunit genes may be explained by the occurence of two, successive duplication events during vertebrate evolution, and suggest that Ly-9 may also participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction.


Gene Mapping Sequence Similarity Gene Duplication Genetic Linkage Human Chromosome 
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Copyright information

© Springer-Verlag 1995

Authors and Affiliations

  • Stephen F. Kingsmore
    • 1
  • Carolyn A. Souryal
    • 2
  • Mark L. Watson
    • 2
  • Dhavalkumar D. Patel
    • 2
  • Michael F. Seldin
    • 3
  1. 1.Departments of Medicine and Pathology, and Center for Mammalian GeneticsUniversity of FloridaGainesvilleUSA
  2. 2.Department of MedicineDuke University Medical CenterDurhamUSA
  3. 3.Departments of Medicine and MicrobiologyDuke University Medical CenterDurhamUSA

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