Inching toward reality: An improved likelihood model of sequence evolution
- Cite this article as:
- Thorne, J.L., Kishino, H. & Felsenstein, J. J Mol Evol (1992) 34: 3. doi:10.1007/BF00163848
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Our previous evolutionary model is generalized to permit approximate treatment of multiple-base insertions and deletions as well as regional heterogeneity of substitution rates. Parameter estimation and alignment procedures that incorporate these generalizations are developed. Simulations are used to assess the accuracy of the parameter estimation procedure and an example of an inferred alignment is included.
Key wordsAlignment Maximum likelihood procedure Dynamic programming Evolutionary model Insertion-deletion model
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