International Ophthalmology

, Volume 14, Issue 5–6, pp 345–347

Xanthine oxidase generation of toxic oxygen metabolites in acute uveitis

  • George E. MarakJr.
  • Gerd O. Till
  • Peter A. Ward
Article

Summary

Lodoxamide, a xanthine oxidase inhibitor, has antiphlogistic effects in the treatment of acute uveitis. The role of xanthine oxidase generated free radicals is discussed.

Key words

free radicals lodoxamide phocoanaphylactic endophthalmitis uveitis xanthine oxidase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Marak GE, De Kozak Y, Faure JP. Free Radicals and Antioxidants in the Pathogenesis of Eye Diseases in I. Emeret and L. Packer eds. Antioxidants in Therapy and Preventative Medicine, Plenum Press, London (in press) (1989).Google Scholar
  2. 2.
    Phan SH, Gannon DE, Varoni J, Regan US, Ward PA. Xanthine Oxidase activity in rat pulmonary endothelial cells and its alteration by activated neutrophils. Am J Pathol (in press) (1989).Google Scholar
  3. 3.
    Babior BM. Oxygen dependent microbiol killing by phagocytes. New England J Med 1978; 298: 659–668.Google Scholar
  4. 4.
    Friedl HP, Till GO, Ryan US, Ward PA. Mediator induced activation of xanthine oxidase in endothelial cells. Fed Proc (in press) (1989).Google Scholar
  5. 5.
    Friedl HP, Till GO, Trentz O, Ward PA. Roles of histamine complement and xanthine oxidase in thermal injury of skin. Am J Pathol (in press) (1989).Google Scholar
  6. 6.
    White GJ. Inhibition of oxidative enzymes by antiallergic drugs. Agents, Actions 1981; 11:503–08.Google Scholar
  7. 7.
    Marak GE, Font RL, Alepa FR. Arthus-type panophtalmitis in rats sensitized to hetrologous lens proteins. Ophthal Res 1977; 9: 162–170.Google Scholar
  8. 8.
    Marak GE, Rao NA, Sevanian A, Zdravokovich V, Till GO, Ward PA. Modulation of experimental phacoanaphylactic endophthalmitis with the antioxidants sodium benzoate and 2,3 dihydroxybenzoic acid. Ophthalmic Res 1987; 19: 120–128.Google Scholar
  9. 9.
    Hallowell B, Gutteridge JMC. Hydroxyl radicals assayed by aromatic hydroxylation and deoxyribose degradation in R.A. Greenwald ed. Handbook of methods for oxygen radical research. CRC press, Boca Raton, 177–180 (1986).Google Scholar
  10. 10.
    Gutteridge JMC, Rowley DA, Hollowell B. Superoxide dependent formation of hydroxyl radicals in the presence of iron salts. Detection of free iron in biological systems of using blomycine dependent degradation of DNA. Biochem J 1981; 199: 263–265.Google Scholar
  11. 11.
    Dalmasso AP, Miller-Eberhard HJ. Hemolytic activity of lipoprotein depleted serum and the effect of certain axions on complement. J Immunol 1966; 97: 680–685.Google Scholar
  12. 12.
    Chapman WE, Ward PA. The complement profile in babesiosis. J Immunol 1976; 117: 935–938.Google Scholar
  13. 13.
    Marak GE, Font RL, Alepa FP, Ward PA. The effects of C3 inactivator factor on the development of experimental lens induced granulomatous endophthalmitis. Ophthal Res 1977; 9: 416–420.Google Scholar
  14. 14.
    Johnson HG, Sheridan AQ. The characterization of lodoxamide, a very active inhibitor of mediator release, in animal and human models of asthma. Agents and Actions 1986; 18: 301–305.Google Scholar
  15. 15.
    Makino H, Ashida Y, Saijo T, Kuriki H, Terao S, Maki Y. Role of leukotrienes in rat reversed arthus pleurisy and the effect of AA861, a 5-lipoxygenase inhibitor. Int Arch Allergy Appl Immunol 1986; 79: 38–44.Google Scholar
  16. 16.
    de Kozak Y, Sainte-Laudy J, Benveniste J, Faure JP. Immediate hypersensitivity in experimental retinal autoimmunity in G. O'Connor, J. Chandler eds. Advances in Immunology and Immunopathology of the Eye. Masson, New York, 125–130 (1985).Google Scholar
  17. 17.
    Hiroi J, Ohara K, Fujitsu T, Fugii T, Motoyama Y, Mori J, Shibayama F. Effects of FR 50948, a new orally active antiallergic agent in experimental allergic models. Japan J Pharmacol 1988; 46: 337–348.Google Scholar
  18. 18.
    Irita K, Fijita I, Takoshige K, Minikami S, Yoshitaki J. Calcium channel antagonist inhibition of superoxide production in human neutrophils. Biochem Pharmacol 1986; 35: 3465–3471.Google Scholar
  19. 19.
    Sery TW, Vogel AW, Folberg R, Petrillo R. Oxygen free radicals in ocular inflammatory disease in uveitis update. Elsevier Science Publishers, Amsterdam, 39–45 (1984).Google Scholar

Copyright information

© Kluwer Academic Publishers 1990

Authors and Affiliations

  • George E. MarakJr.
    • 1
  • Gerd O. Till
    • 2
  • Peter A. Ward
    • 2
  1. 1.Center for Sight, Georgetown UniversityWashingtonD.C.USA
  2. 2.Department of PathologyUniversity of MichiganAnn ArborUSA
  3. 3.AlexandriaUSA

Personalised recommendations