Journal of Neuro-Oncology

, Volume 6, Issue 1, pp 47–52 | Cite as

Brain metastases in osteosarcoma: incidence, clinical and neuroradiological findings and management options

  • Tallie Z. Baram
  • Pamela van Tassel
  • Norman A. Jaffe


Brain metastasis is uncommon in osteosarcoma, but this may be changing with prolonged patient survival in the modern chemotherapy era. We present 5 patients with brain metastases out of 39 with lung metastasis (13%) in a total of 87 osteosarcoma patients.

The clinical manifestations of brain metastases were catastrophic: massive hemorrhage in 2 and status epilepticus in 3. Metastases were single or multiple, and some were osteoblastic. Surgical intervention in 2 cases resulted in dramatic, though transient, clinical improvement.

We advocate periodic neuroradiology screening in osteosarcoma patients with lung metastases, for early detection of brain involvement.

Key words

osteosarcoma brain metastases presentation neuroradiology 


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Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • Tallie Z. Baram
    • 1
    • 2
  • Pamela van Tassel
    • 3
  • Norman A. Jaffe
    • 1
  1. 1.Department of PediatricsThe University of Texas System Cancer Center M. D. Anderson Hospital and Tumor InstituteHoustonUSA
  2. 2.Department of Neuro-OncologyThe University of Texas System Cancer Center M. D. Anderson Hospital and Tumor InstituteHoustonUSA
  3. 3.Department of Diagnostic RadiologyThe University of Texas System Cancer Center M. D. Anderson Hospital and Tumor InstituteHoustonUSA

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