Journal of Molecular Evolution

, Volume 40, Issue 3, pp 326–330

Properties of a general model of DNA evolution under no-strand-bias conditions

  • J. R. Lobry
Article

Abstract

Under the hypothesis of no-strand-bias conditions, the Watson and Crick base-pairing rule decreases the complexity of models of DNA evolution by reducing to six the maximum number of substitution rates. It was shown that intrastrand equimolarity between A and T (A*T*) and between G and C (G*C*) is a general asymptotic property of this class of models. This statistical prediction was observed on 60 long genomic fragments (>50 kbp) from various kingdoms, even when the effect of the two opposite orientations for coding sequences is removed. The practical consequence of the model for estimating the expected number of substitutions per site between two homologous DNA sequences is discussed.

Key words

DNA evolution No-strand bias Coding sequence 

Abbreviations

BPR

Watson and Crick base pairing rule (A:T, G:C)

PRI

Intrastrand type-1 parity rule (ij, m(i,j)m(\(\bar i,\bar j\)))

PRII

Intra strand type-2 parity rule (A*T*, G*C*)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Chargaff E (1979) How genetics got a chemical education. Ann NY Acad Sci 325:345–360Google Scholar
  2. Elson D, Chargaff E (1955) Evidence of common regularities in the composition of pentose nucleic acids. Biochim Biophys Acta 17: 367–376Google Scholar
  3. Foster DM, Jacquez JA (1975) Multiple zeros for eigenvalues and the multiplicity of traps of a linear compartmental system. Math Biosci 26:89–97Google Scholar
  4. Jacquez JA, Simon CP (1993) Qualitative theory of compartmental systems. SIAM Rev 35:43–79Google Scholar
  5. Li WH, Wu CI, Luo CC (1984) Nonrandomness of point mutation as reflected in nucleotide substitutions in pseudogenes and its evolutionary implications. J Mol Evol 21:58–71Google Scholar
  6. Prabhu VV (1993) Symmetry observation in long nucleotide sequences. Nucleic Acids Res 21:2797–2800Google Scholar
  7. Rudner R, Karkas JD, Chargaff E (1968) Separation of B. subtilis DNA into complementary strands: III. Direct analysis (1968) Proc Natl Acad Sci USA 60:921–922Google Scholar
  8. Sueoka N (1993) Directional mutation pressure, mutator mutations, and dynamics of molecular evolution. J Mol Evol 37:137–153Google Scholar
  9. Sueoka N (1995) Intrastrand parity rules of DNA base composition and usage biases of synonymous codons. J Mol Evol 40:318–325Google Scholar
  10. Watson JD, Crick FHC (1953) A structure for deoxyribose nucleic acid. Nature 171:737–738Google Scholar
  11. Wu CI, Maeda N (1987) Inequality in mutation rates of the two strands of DNA. Nature 327:169–170Google Scholar
  12. Yang Z (1994) Estimating the pattern of nucleotide substitution. J Mol Evol 39:105–111Google Scholar

Copyright information

© Springer-Verlag New York Inc. 1995

Authors and Affiliations

  • J. R. Lobry
    • 1
  1. 1.Laboratoire de Biométrie, CNRS URA 243Université Claude BernardVilleurbanne CedexFrance

Personalised recommendations