Documenta Ophthalmologica

, Volume 77, Issue 3, pp 193–200 | Cite as

Color pattern-reversal visual evoked potential in eyes with ocular hypertension and primary open-angle glaucoma

  • Yi-Hao Shih
  • Zhu-Jing Huang
  • Ching-E Chang


Color pattern-reversal visual evoked potential testing was performed in 99 normal eyes, 27 eyes with ocular hypertension and 30 eyes with primary open-angle glaucoma with the use of black-white, black-red and black-blue color checkerboard stimuli. The PI wave peak time and amplitude of the eyes with ocular hypertension and glaucoma were significantly different from those of age-similar normal eyes, especially on the black-red and black-blue checkerboards (p < 0.001). The differences between the ocular hypertensive and glaucomatous eyes were of less significance. The P1 peak time difference between black-white and black-red checkerboards may serve as an important parameter in the early diagnosis of glaucoma.

Key words

Color pattern-reversal visual evoked potential ocular hypertension primary open-angle glaucoma 



ocular hypertension


primary open-angle glaucoma


normal control


color pattern-reversal visual evoked potential


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  1. 1.
    Towle UL, Moskowitz AN, Sokol S, Schwartz BN. The VHP in glaucoma and ocular hypertension. Invest Ophthalmol Vis Sci 1983: 24: 175–83.Google Scholar
  2. 2.
    Rouland JF, Hache JC. Visual-evoked potentials in glaucoma and ocular hypertension. Glaucoma 1990; 12: 77–78.Google Scholar
  3. 3.
    Bellizzi M, Cardia L, Lamorgese C, Pomes L, Sorrento G, Ferrante G. Pattern visual-evoked potentials in early diagnosis of open-angle glaucoma. Glaucoma 1988; 10: 60–61.Google Scholar
  4. 4.
    Bobak P, Bodis-wollner I, Harnois C, Maffei L, Mylin L, Podos S, Thornton J. Pattern ERGs and VEPs in glaucoma and multiple sclerosis. Am J Ophthalmol 1983; 96: 72–83.Google Scholar
  5. 5.
    Izumi Nakajima, Emiko Adachi. Pattern VECPs in ocular hypertension. Folia Ophthalmol Jpn 1984; 35: 1556–60.Google Scholar
  6. 6.
    Jian GE, Lezheng WU, Dezheng WU. Color pattern visual evoked potential in glaucomatous optic nerve atrophy. Eye Science 1986; 2: 154–57.Google Scholar
  7. 7.
    Huang T-t. The correspondence of Zi-ping Yu, Ishihara plates for color vision. Chinese J Ophthalmol 1965; 12: 84–86.Google Scholar
  8. 8.
    Coganek L, Ingvar DH. Color specific features of visual cortical responses in man evoked by monochromatic flashes. Acta Physiol Scand 1969; 76: 82–92.Google Scholar
  9. 9.
    Wu W-C, Liu J-y, Zheng Z-l. Analysis of color evoked potentials in man. Acta Biochimica et Biophysica Sinica 1985; 6: 26–29.Google Scholar
  10. 10.
    Vingrys AJ, King-smith PE, Benes SC. Equiluminous color deficits are greater than achromatic losses in cases of toxoplasmosis. In: Drum B, Verriest G, eds. Dordrecht/Boston/London: Kluwer Academic Publishers, 1987: 217–27.Google Scholar
  11. 11.
    Quigley HA, Addioks EM, Green WR, Maumenee AE. Optic nerve damage in human glaucoma. Arch Ophthalmol 1981; 99: 635–49.Google Scholar
  12. 12.
    Atkin A, Wollner IB, Wolkstein M, Moss A, Podos SM. Abnormalities of central contrast sensitivity in glaucoma. Am J Ophthalmol 1979; 88: 205–11.Google Scholar
  13. 13.
    Ross JE, Bron AJ, Reeves BC, Emmerson PG. Detection of optic nerve damage in ocular hypertension. Br J Ophthalmol 1985; 69: 897–903.Google Scholar
  14. 14.
    Adams AJ, Rodic R, Husted R, Stamper R. Spectral sensitivity color discrimination changes in glaucoma and glaucoma-suspect patients. Invest Ophthalmol Vis Sci 1982; 23: 516–24.Google Scholar
  15. 15.
    Drance SM, Lanowski R, Schulzer M, Douglas GR. Acquired color vision changes in glaucoma. Arch Ophthalmol 1981; 99: 829–36.Google Scholar
  16. 16.
    Stamper RL. The effect of glaucoma on central visual function. Trans Am Ophthalmol Soc 1984; 82: 792–826.Google Scholar
  17. 17.
    Huang Z-j, Chang C-e. Dark adaptation in primary glaucoma. Transaction of the 1964 annual conference of Beijing association in ophthalmology, 1964: 34–36.Google Scholar
  18. 18.
    Trich GL. Retinal potentials in patients with primary open-angle glaucoma. Invest Ophthalmol Vis Sci 1985; 26: 1750–58.Google Scholar
  19. 19.
    Ikeda H, Tremain KE, Sanders MD. Neurophysiological investigation in optic nerve disease: combined assessment of VEP and ERG. Br J Ophthalmol 1978; 62: 227–39.Google Scholar
  20. 20.
    Fishman RS. The visual-evoked cortical response in nightblindness. Am J Ophthalmol 1966; 62: 1166–76.Google Scholar
  21. 21.
    Sokol S. VEPs: theory, techniques and clinical applications. Survey Ophthalmol 1976; 21: 18–44.Google Scholar

Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Yi-Hao Shih
    • 1
  • Zhu-Jing Huang
    • 1
  • Ching-E Chang
    • 1
  1. 1.Beijing Institute of OphthalmologyBeijingChina

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