Journal of Molecular Evolution

, Volume 39, Issue 6, pp 631–643 | Cite as

Tracing the spread of fibronectin type III domains in bacterial glycohydrolases

  • Elizabeth Little
  • Peer Bork
  • Russell F. Doolittle


The evolutionary spread of 22 fibronectin type III (Fn3) sequences among a dozen bacterial enzymes has been traced by searching databases with the non-Fn3 parts of the enzyme sequences. Numerous homologues were found that lacked the Fn3 domains. In each case the related sequences were aligned, phylogenetic trees were constructed, and the occurrences of Fn3 units on the trees were noted. Comparison with phylogenetic trees prepared from the Fn3 segments themselves allowed inferences to be made about when the Fn3 units were shuffled into their present positions.

Key words

Fibronectin type III Bacteria Glycohydrolases Phylogeny Horizontal gene transfers 


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Copyright information

© Springer-Verlag New York Inc 1994

Authors and Affiliations

  • Elizabeth Little
    • 1
  • Peer Bork
    • 1
  • Russell F. Doolittle
    • 1
  1. 1.Center for Molecular GeneticsUniversity of CaliforniaSan Diego, La JollaUSA

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