European Journal of Epidemiology

, Volume 8, Issue 3, pp 321–325 | Cite as

The ecology of Cryptococcus neoformans

  • D. Ellis
  • T. Pfeiffer


Environmental isolations have established that Cryptococcus neoformans var. gattii serotype B appears to have a specific ecological association with Eucalyptus camaldulensis. The global distribution of the tree appears to correspond to the epidemiologic distribution of cryptococcosis caused by C. neoformans var. gattii. The epidemiology of cryptococcosis can primarily be explained by exposure to an infective aerosolized inoculum, such as basidiospores released from specific host plants and/or desiccated blastoconidia (yeast cells) disseminated from accumulations of dried pigeon dung. The ecology of C. neoformans still remains largely unresolved, studies on the host-parasite interaction between serotype B and E. camaldulensis are still in progress, and extensive environmental searches are now underway to determine the natural habitats of serotypes A, C and D.

Key words

Cryptococcus neoformans var. gattii Ecology 


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  1. 1.
    Ajello L. (1970): The Medical Mycological Iceberg. In: Pan American Health Organization, Proceedings (of the) International Symposium of the Mycoses, Washington, D.C. - pp.3–12 (PAHO Scientific Publication No. 205.)Google Scholar
  2. 2.
    BulmerG.S. (1990): Twenty-five years with Cryptococcus neoformans - Mycopathologia 109: 111–112.Google Scholar
  3. 3.
    ChippendaleG.M. (1988): Flora of Australia Volume 19 - Bureau of Flora and Fauna - Australian Government Publishing Service - Canberra.Google Scholar
  4. 4.
    ClancyM.N., FleischmannJ., HowardD.H., Kwon-ChungK.J. and ShimizuR.Y. (1990): Isolation of Cryptococcus neoformans gattii from a patient with AIDS in Southern California - J. Infect. Dis. 161: 809.Google Scholar
  5. 5.
    CohenJ. (1982): The pathogenesis of cryptococcosis -Journal of Infection 5: 109–116.Google Scholar
  6. 6.
    DimechW.J. (1991): Diagnosis, identification and epidemiology of Cryptococcus neoformans infection -Australian Journal of Medical Laboratory Science 12: 13–21.Google Scholar
  7. 7.
    EllisD.H. (1987): Cryptococcus neoformans var. gattii in Australia - J. Clin. Microbiol. 25: 430–431.Google Scholar
  8. 8.
    EllisD.H. and PfeifferT.J. (1990): Natural habitat of Cryptococcus neoformans var. gattii - J. Clin. Microbiol. 28: 430–431.Google Scholar
  9. 9.
    EllisD.H. and PfeifferT.J. (1990): Ecology, life cycle, and infectious propagule of Cryptococcus neoformans -The Lancet 366: 923–925.Google Scholar
  10. 10.
    IkedaR., ShinodaT., FukazawaY. and KaufmanL. (1982): Antigenic characterization of Cryptococcus neoformans serotypes and its application to serotyping of clinical isolates - J. Clin. Micro. 16(1): 22–29.Google Scholar
  11. 11.
    Kwon-ChungK.J., BennettJ.E. and RhodesJ.C. (1982): Taxonomic studies on Filobasidiella species and their anamorphs - Antonie van Leeuwenhoek J. Clin. Microbiol. 48: 25–38.Google Scholar
  12. 12.
    Kwon-ChungK.J., PolacheckI. and BennettJ.E. (1982): Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (Serotypes A and D) and Cryptococcus neoformans var. gattii (Serotypes B and C) - Journal of Clinical Microbiology 15(3): 535–537.Google Scholar
  13. 13.
    Kwon-ChungK.J. and BennettJ.E. (1984): High prevalence of Cryptococcus neoformans var. gattii in tropical and subtropical regions - Zbl. Bakt. Hyg. A 257: 213–218.Google Scholar
  14. 14.
    Kwon-ChungK.J. and FellJ.W. (1984): Genus 2. Filobasidiella Kwon-Chung. in The yeasts a taxonomic study edited by N.J.W. Kreger-van Rij -Elselvier Science Publishers - Amsterdam.Google Scholar
  15. 15.
    Kwon-Chung K.J. and Yarma A. (1989): Cryptococcus neoformans - Ecology and epidemiology. In: 3rd Symposium Topics in Mycology - Mycoses in AIDS Patients - The Pasteur Institute p. 55–56.Google Scholar
  16. 16.
    Kwon-ChungK.J., Yarma, A. and HowardD.H. (1990): Ecology of Cryptococcus neoformans and prevalence of its two varieties in AIDS and non-AIDS associated Cryptococcosis. In: Mycoses in AIDS Patients, edited by H. Vanden Bossche et al., Plenum Press -New York.Google Scholar
  17. 17.
    Murphy J.W. (1989): Cryptococcosis. In: Immunology of the Fungal Diseases - edited by R.A. Cox - CRC Press - Inc.Google Scholar
  18. 18.
    PfeifferT.J. and EllisD.H. (1990): Environmental isolation of Cryptococcus neoformans var. gattii from California - J. Infect. Dis. 163: 929–930.Google Scholar
  19. 19.
    RipponJ.W. (1988): Medical Mycology: The pathogenic fungi and the pathogenic actinomycetes -3rd edition, W.B. Saunders Co. W.B. Saunders Co -Philadelphia.Google Scholar
  20. 20.
    RuizA., FromtlingR.A. and BulmerG.S. (1981): Distribution of Cryptococcus neoformans in a natural site - Infection and Immunity 31: 560–563.Google Scholar
  21. 21.
    21.SmithJ.M.B. (1989): Cryptococcosis (Chapter 3) in Opportunistic Mycoses of Man and Other Animals -C.A.B. International Mycological Institute - BPCC Wheaton Ltd. - Exeter.Google Scholar
  22. 22.
    StaibF. (1987): Cryptococcosis in AIDS -Mycological - diagnostic and epidemiological observations - Aids Forschung (AIFO) 2: 363–382.Google Scholar
  23. 23.
    Zacharin R.F. (1978): Emigrant eucalypts: gum trees as exotics - Melbourne University Press.Google Scholar

Copyright information

© Gustav Fischer 1992

Authors and Affiliations

  • D. Ellis
    • 1
  • T. Pfeiffer
    • 1
  1. 1.Mycology Unit — Adelaide Children's HospitalNorth AdelaideAustralia

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