Effects of repeated ivermectin treatment in onchocerciasis
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Abstract
A group of 87 onchocerciasis patients from a hyperendemic area without vector control was treated with a single dose of 150 μg/kg ivermectin. A second, third and fourth dose was administered 5, 12 and 17 months later to 44, 35 and 25 patients. Skin snip loads reduced substantially following each consecutive dose. However, after three doses 44% of the patients remained skin snip positive. Side-effects decreased from 32.2% requiring medical treatment at the first dose to none after the fourth dose. From this study it was concluded that a complete eradication of microfilariae in skin snips in severely infected persons living in a hyperendemic area without vector control is probably not feasible. Medical supervision for the observation of side-effects after the third dose can be limited.
Key words
Ivermectin onchocerciasis side-effects skin snipPreview
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References
- 1.Greene BM, Taylor HR, Cupp EW, Murphy RP, White AT, Aziz MA, Schulz-Key H, D'Anna SA, Newland HS, Goldschmidt LP, Auer C, Hanson AP, Freeman SV, Reber EW, Williams PN. Comparison of ivermectin and diethylcarbamazine in the treatment of onchocerciasis. N Eng J Med 1985; 313: 133–138.Google Scholar
- 2.Van der Lelij A, Rothova A, Klaassen-Broekema N, Wilson WR, Barbe RF, Stilma JS. Decrease in adverse reactions after repeated ivermectin treatment in onchocerciasis. Doc Ophthalmol 1990; 75: 215–224.Google Scholar
- 3.Rothova A, Van der Lelij A, Stilma JS, Wilson WR, Barbe RF. Side-effects of ivermectin in treatment of onchocerciasis. Lancet 1989; i: 1439–1441.Google Scholar
- 4.Rothova A, Van der Lelij A, Stilma JS, Klaassen-Broekema N, Wilson WR, Barbe RF. Ocular involvement in patients with onchocerciasis after repeated treatment with ivermectin. Am J Ophthalmol 1990; 110: 6–16.Google Scholar
- 5.Stilma JS, Rothova A, Van der Lelij A, Wilson WR, Barbe RF. Ocular and systemic side effects following invermectin treatment in onchocerciasis patients from Sierra Leone. Acta Leidensia 1990 (1 + 2): 207–210.Google Scholar
- 6.Greene BM, Dukuly ZD, Muñoz B, White AT, Pacqué M, Taylor HR. A comparison of 6-, 12- and 24-monthly dosing with ivermectin for treatment of onchocerciasis. J Inf Dis 1991; 163: 376–380.Google Scholar
- 7.Pacqué M, Mũnoz B, Greene BM, Taylor HR. Community-based treatment of onchocerciasis with ivermectin: safety, efficacy, and acceptability of yearly treatment. J Inf Dis 1991; 163: 381–385.Google Scholar
- 8.White AT, Newland HS, Taylor HR, Erttmann KD, Keyvan-Larijani E, Nara A, Aziz MA, D'Anna SA, Williams PN, Greene BM. Controlled trial and dose-finding study of ivermectin for treatment of onchocerciasis. J Inf Dis 1987; 156: 463–470.Google Scholar
- 9.Remme JHF. The epidemiology and control of onchocerciasis in West-Africa [Dissertation]. Rotterdam, Erasmus University, The Netherlands. 1989. 195 pp.Google Scholar
- 10.Cupp EW, Bernardo MJ, Kiszweski AE, Collins RC, Taylor HR, Aziz MA, Greene BM. The effects of ivermectin on transmission of Onchocerca volvulus. Science 1986; 231: 740–742.Google Scholar