The epidemiology of nosocomial Pseudomonas cepacia infections: Endemic infections
Pseudomonas cepacia has recently emerged as an important nosocomial pathogen. We analyzed a national nosocomial infections database, the National Nosocomial Infections Surveillance (NNIS) system, to describe the epidemiology of endemic nosocomial P. cepacia infections. Between 1980 and 1985, the P. cepacia nosocomial infection rate was 2.4 per 100,000 patient discharges. During this period, there was a significant increase in the P. cepacia infection rate. The highest infection rate was reported from large medical school-affiliated hospitals. Over 90% of the infections were reported from medicine and surgery services. The most frequently reported site of infection was the lower respiratory tract (31%), followed by blood (20%) and the urinary tract (20%). Nosocomial P. cepacia infections are often associated with mortality, particularly when they involve the lung. These data confirm the hypothesis that P. cepacia is an emerging nosocomial pathogen and suggest that the epidemiology of endemic infections differs from that reported for epidemic inflections.
Key wordsNosocomial infections P. cepacia Epidemiology
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- 1.Jarvis W.R., White J.W., Munn V.P., Mosser J.L., Emori T.G., Culver D.H., Thornsberry C., Hughes J.M. (1984): Centers for Disease Control. Nosocomial Infection Surveillance 1983. In: CDC Surveillance summaries. 33: 9ss–23ss.Google Scholar
- 2.Lennette E.H., Balows A., Hausler J.W.J., ShadomyH.J.et al. (1985): Manual of Clinical Microbiology. Fourth edition. American Society for Microbiology, Washington, DC.Google Scholar
- 3.Martone W.J., Tablan O.C. and Jarvis W.R. (1987): The Epidemiology of nosocomial epidemic Pseudomonas cepacia infections. - Eur. J. Epidemiol. 3: 222--232.Google Scholar
- 4.Rothman K.J., Boice J.D. Jr. (1979): Trend Analysis1444 for Proportions. Epidemiologic analysis with a programable calculator. Department of Health, Education, Welfare, National Institutes of Health, Publication No. 70-1645, June.Google Scholar
- 5.Tablan O.C., Chorba T.L., Schidlow D.V., White J.W., Hardy K.A., Gilligan P.H., Morgan W.M., Carson L.A., Martone W.J., Jason J.M., Jarvis W.R. (1985): Pseudomonas cepacia colonization in patients with cystic fibrosis: Risk factors and clinical outcome. - J. Pediatr. 107: 382–387.Google Scholar
- 6.Tablan O.C., Williams W.W. and Martone W.J. (1985): Infection Control in Pulmonary Function Laboratories. - Infect. Contr. 6: 442–444.Google Scholar
- 7.Tablan O.C., Martone W.J., Doershuk C.F., SternR.C., Thomassen M.J., Klinger J.D., White J.W., Carson L.A. and Jarvis W.R. (1987): Risk factors and outcome associated with Pseudomonas cepacia colonization of the respiratory tract of patient with cystic fibrosis. - Chest 91: 527–533.Google Scholar
- 8.Tablan O.C., Carson L.A., Cusick L.B., Bland L.A., Martone W.J. and Jarvis W.R. (1987): Use of selective media in isolating Pseudomonas cepacia from simulated sputum specimens of cystic fibrosis patients: Results of laboratory proficiency tests. - J. Clin. Microbiol. 25: 485–487.Google Scholar