Longterm remission of multiple brain metastases with tamoxifen
A case of multiple brain metastases from breast carcinoma treated with tamoxifen is described. She remained in remission for 58 months and is still alive after 82+ months of hormone therapy. The case indicates that hormonal treatment may be very effective in the management of brain metastases from breast carcinoma.
Key wordsbrain metastases breast neoplasms drug therapy tamoxifen quality of life
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- 1.Sparrow GEA, Rubens RD: Brain metastases from breast cancer: Clinical course, prognosis and influence of treatment. Clin Oncol 7: 291–301, 1981Google Scholar
- 2.Rosner D, Nemoto T, Lane WW: Chemotherapy induces regression of brain metastases in breast carcinoma. Cancer 58: 832–839, 1986Google Scholar
- 3.Reitan RM: Trail making test. Manual for administration, scoring and interpretation. Dept of Neurology, Section of Neuropsychology, Indiana University Medical Center, Indianapolis, 1958Google Scholar
- 4.Wechsler D: The measurement and appraisal of adult intelligence. Williams and Wilkings, Baltimore, 4 ed., 1958Google Scholar
- 5.Cary RW, Davis JM, Zervas NT: Tamoxifen-induced regression of cerebral metastases in breast carcinoma. Cancer Treatm Rep 65: 793–795, 1981Google Scholar
- 6.Tominaga T: Characteristics and treatments of metastases to the central nervous system in patients with breast cancer. Jap J Cancer Clin 30: 987–993, 1984Google Scholar
- 7.Pugesgaard T, von Eyben FE: Bilateral optic neuritis evolved during tamoxifen treatment. Cancer 58: 33–35, 1986Google Scholar
- 8.Bowman SP, Leake A, Morris ID: Hypothalamic, pituitary and uterine cytoplasmic and nuclear oestrogen receptors and their relationship to the serum concentration of tamoxifen and its metabolite, 4-hydroxytamoxifen, in ovariectomized rat. J Endocrin 94: 167–175, 1982Google Scholar
- 9.Johnson BE, Necker B, Goff BB II, Petronas N, Krehbiel MA, Makuch RW, McKenna G, Glatstein E, Ihde DC: Neurologic, neuropsychologic, and computed cranial tomography scan abnormalities in 2- to 10-year survivors of small-cell lung cancer. J Clin Oncol 3: 1659–1667, 1985Google Scholar
- 10.Taylor SC IV, Gelman RS, Falkson G, Cummings FJ: Combination chemotherapy compared to tamoxifen as initial therapy for stage IV breast cancer in elderly women. Ann Intern Med 104: 455–461, 1986Google Scholar