Journal of Neuro-Oncology

, Volume 10, Issue 2, pp 165–171 | Cite as

Brain lesions following combined treatment with methotrexate and craniospinal irradiation

  • Cruz-Sanchez F. F. 
  • J. Artigas
  • J. Cervos-Navarro
  • M. L. Rossi
  • R. Ferszt
Clinical Study


Eight patients with meningeal seeding by carcinoma or lymphomas were treated with intravenous (i.v.) and/or intrathecal ( Methotrexate (MTX). Seven patients received additional craniospinal irradiation and in all seven a fatal encephalopathy developed.

On the bases of clinical and morphological findings we identified an acute and a delayed form of encephalopathy and concluded that the concurrent administration of Methotrexate and of craniospinal irradiation increases considerably the risk of brain damage.

Key words

leucoencephalopaty Methotrexate central nervous system craniospinal irradiation 


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Copyright information

© Kluwer Academic Publishers 1991

Authors and Affiliations

  • Cruz-Sanchez F. F. 
    • 1
  • J. Artigas
    • 2
  • J. Cervos-Navarro
    • 2
  • M. L. Rossi
    • 3
  • R. Ferszt
    • 2
  1. 1.Neurological Tissue Bank, Hospital Clinico I ProvincialUniversity of BarcelonaSpain
  2. 2.Institute of NeuropathologyFree University of BerlinGermany
  3. 3.Dept. of NeuropathologyMidland Centre for Neurology & Neurosurgery, Holly Lane, SmethwickWarley, BirminghamUK

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