European Journal of Epidemiology

, Volume 8, Issue 4, pp 503–508 | Cite as

Maternal diabetes: The risk for specific birth defects

  • M. A. Ramos-Arroyo
  • E. Rodriguez-Pinilla
  • J. F. Cordero
Article

Abstract

We studied the risk for specific birth defects among infants of mothers with gestational and chronic diabetes using data collected by the Spanish Collaborative Study of Congenital Malformations (ECEMC). For the years 1976 to 1985, we identified 10,087 infants with malformations and 9,994 control infants; 155 of the case infants and 89 of the controls were born to diabetic mothers. The crude odds ratio for any minor or major defect and insulin-treated diabetes was 5.5 (95% CI =1.2, 24.8), and for major malformations it was 8.7 (95% CI =1.8, 34.7). The risk for defects involving the central nervous system (CNS), skeletal system and cardiovascular system were significantly increased. Infants of non-insulin-treated diabetic mothers were 2.9 times more likely to have a major congenital birth defect (95% CI =1.2, 7.2): The crude odds ratio for any major or minor defect and mothers with gestational diabetes requiring insulin was 1.9 (95% CI = 1.1, 3.4). Similar risk was observed for major defects (OR =1.9, 95% CI =1.0, 3.7). These results suggest that infants of insulin-treated diabetic mothers have an increased risk of developing malformations of the CNS, cardiovascular system and skeletal system. We also found an increased risk for specific defect categories among infants of mothers with gestational diabetes treated with insulin.

Key words

Abnormality Birth defect Maternal diabetes mellitus Pregnancy 

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Copyright information

© Gustav Fischer 1992

Authors and Affiliations

  • M. A. Ramos-Arroyo
    • 1
  • E. Rodriguez-Pinilla
    • 2
  • J. F. Cordero
    • 3
  1. 1.Servicio de GeneticaHospital Virgen del CaminoNavarraSpain
  2. 2.Estudio Collborativo Español de Maformaciones Congénitas (ECEMC)Hospital Universitario San Carlos - Facultad de Medicina - Universidad ComplutenseMadridSpain
  3. 3.Birth Defects and Genetic Diseases Branch - Division of the Birth Defects and Developmental Disabilities - Center for Environmental Health and Injury Control - Centers for Disease Control Public Health ServiceU.S. Department of Health and Human ServicesAtlantaUSA

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