European Journal of Epidemiology

, Volume 8, Supplement 1, pp 48–53 | Cite as

Serum lipoprotein profile in the Mediterranean variant of glucose-6-phosphate dehydrogenase deficiency

  • S. Muntoni
  • B. Batetta
  • S. Dessi
  • Sa. Muntoni
  • P. Pani
Article

Abstract

Sardinian males with erythrocyte glucose-6-phosphate dehydrogenase (G-6-PD) deficiency have lower serum levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (ApoB), compared to normals. Since the enzyme deficiency is expressed also in nucleated cells, we studied cholesterol (C) and DNA synthesis and LDL-receptor expression in freshly isolated circulating mononuclear cells from normal and G-6-PD-deficient Sardinians. Synthesis of C (as 14C-acetate incorporation) and of DNA (as 3H-thymidine incorporation) was clearly reduced, both in basal state and after PHA stimulation, in G-6-PD-deficient cells compared to normal cells. On the other hand, no clear influence of G-6-PD deficiency on LDL-receptor expression could be demonstrated. The Mediterranean variant of G-6-PD deficiency is characterized, whatever the metabolic mechanism may be, by a serum lipoprotein pattern of reduced atherogenicity.

Key words

ApoB Cholesterol G-6-PD deficiency LDL-cholesterol 

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Copyright information

© Gustav Fischer 1992

Authors and Affiliations

  • S. Muntoni
    • 1
  • B. Batetta
    • 2
  • S. Dessi
    • 1
  • Sa. Muntoni
    • 2
  • P. Pani
    • 2
  1. 1.Centro Regionale per le Malattie Dismetaboliche e l'ArteriosclerosiOspedale “G. Brotzu” (S. Michele)CagliariItaly
  2. 2.Istituto di Farmacologia e Patologia BiochimicaUniversità di Cagliari - CagliariItaly

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