European Journal of Epidemiology

, Volume 4, Issue 2, pp 206–211 | Cite as

Serum thiocyanate levels as an objective measure of smoking habits in epidemiological studies

  • A. Spagnolo
  • S. Torsello
  • G. Morisi
  • E. Petrozzi
  • R. Antonini
  • G. Ricci
  • G. C. Urbinati
  • A. Menotti

Abstract

The relationship between smoking habits and plasma thiocyanate levels has been evaluated in four adult samples of the general population containing men and women aged 20–84 and in a sample of 11-year-old non-smoking children of both sexes, for a total of 7577 individuals.

Mean levels of plasma thiocyanate was found be approximately 20 μmol/l in children, 30 μmol/l in non-smoking adults and increasingly higher in smoking adults.

The slopes of the regression equations of thiocyanate on cigarettes smoked per day range from 3.041 to 5.740, with correlation coefficients of from 0.638 to 0.809. In another occupational sample of 280,2 men aged 46 to 65, where the correlation coefficient (between cigarette consumption and thiocyanate) was only 0.49, plasma thiocyanate was a better predictor of 4 year fatal events than cigarette consumption, 4 other covariates being considered in the same mulivariate model.

Key words

Smoking habits Serum thiocyanate Epidemiology 

References

  1. 1.
    FossO.P., Lund-LarsenP.G. (1986): Serum thiocyanate and smoking: interpretation of serum thiocyanate levels observed in a large health study.- Scand. J, Clin. Lab. Invest., 46: 245–251.Google Scholar
  2. 2.
    GardnerM.J., McCarthyL., JurkoW.J. (1984): Relationship of serum thiocyanate concentrations to smoking characteristics. - J. Toxicol. Environ. Health., 14: 393–406.Google Scholar
  3. 3.
    Giampaoli S., Menotti A., Morisi G., Righetti G., Capocaccia R. e il Gruppo di Ricerca del Progetto Monitoraggio Malattie Cardiovascolari Area Latina (1987): Distribuzione di alcuni fattori di rischio cardiovascolare nell'Area Latina - Monitoraggio Malattie Cardiovascolari. in press on Cardiologia.Google Scholar
  4. 4.
    HillP., HaleyN.J., WinderE.L. (1983): Cigarette smoking: carboxyhemoglobin, plasma nicotine, cotinine and thiocyanate vs self-reported smoking data and cardiovascular disease. - J. Chronic Dis., 36 (6): 439–449.Google Scholar
  5. 5.
    Italian Research Group of the Seven Countries Study (1986): Twenty-five year incidence and prediction of coronary heart disease in two Italian rural population samples. - Acta Cardiologica, 41: 283–299.Google Scholar
  6. 6.
    JarvisM., WestR., Tunstall-PedoeH., VeseyC. (1984): An evaluation of the intervention against smoking in the Multiple Risk Factors Intervention Trial. - Prev. Medic., 13: 501–509.Google Scholar
  7. 7.
    KornitzerM., VanbemeldonckA., BourdouxP., DeBackerG. (1983): Belgian heart disease prevention project: comparison of self-reported smoking behaviour with serum thiocyanate concentrations. -J. Epidemiol. Community Health, 37: 132–136.Google Scholar
  8. 8.
    MorisiG., FarinaP., MacchiaT. (1979): Valutazione obiettiva dell'assunzione di fumo tramite la determinazione del tiocianato sierico. - Ann. Ist. Sup. San., 15: 263–272.Google Scholar
  9. 9.
    PechacekT.F., FolsomA.R., GuadermarisR., JacobsD.R., LuepkerR.V., GillumR.F., BlackburnH. (1985): Smoke exposure in pipe and cigar smokers: serum thiocyanate measures. - JAMA, 254: 3330–3332.Google Scholar
  10. 10.
    RicciG., AngelicoF. (1980): Smoking and coronary heart disease: current status of the problem in Italy and experiences of the Rome Project of coronary heart disease prevention. In: Atherosclerosis Reviews, 7: Measurement and control of cardiovascular risk factors. Ruth Hegyeli ed., Raven Press, New York.Google Scholar
  11. 11.
    The Research Group ATS-RF2-ob. 43 of the Italian National Research Council (1987) : Time trends of some cardiovascular risk factors in Italy. Results from the Nine Community Study. In press on Amer; J. Epidemiol.Google Scholar
  12. 12.
    TorselloS., SpagnoloA., LardieriL., BuongiornoA.M., MancinelliA., MorisiG., BaldiniF., CicconeW., IsottonL.A., MenottiA., RighettiG. (1986): Precursori dell'arteriosclerosi in un campione di popolazione infantile dell'Area Latina. - Clin. Terap. Cardiovasc., 5: 241–252.Google Scholar
  13. 13.
    ToumilehtoJ., TanskanenA., SolomenJ.T., NissinenA., KoskelaK. (1986): Effects of smoking and stopping smoking on serum high-density lipoprotein cholesterol levels in a representative population sample. - Prev. Medic., 15: 35–45.Google Scholar

Copyright information

© Kluwer Academic Publishers 1988

Authors and Affiliations

  • A. Spagnolo
    • 1
  • S. Torsello
    • 1
  • G. Morisi
    • 2
  • E. Petrozzi
    • 2
  • R. Antonini
    • 3
  • G. Ricci
    • 3
  • G. C. Urbinati
    • 3
  • A. Menotti
    • 1
  1. 1.Laboratorio di Epidemiologia e BiostatisticaIstituto Superiore di SanitàRomaItaly
  2. 2.Laboratorio di Biochimica CtinicaIstituto Superiore di SanitàRoma
  3. 3.Istituto di Terapia Medica SistematicaUniversità ≪ La Sapienza ≫Roma

Personalised recommendations