Biometals

, Volume 8, Issue 3, pp 205–208

Increased urinary zinc excretion in cancer patients is linked to immune activation and renal tubular cell dysfunction

  • Bohuslav Melichar
  • František Malíř
  • Pavel Jandík
  • Eva Malířová
  • Jaroslava Vávrová
  • Jindřiška Mergancová
  • Zbyněk Vobořil
Article

Abstract

Urinary zinc excretion is known to be increased in cancer patients, but the pathogenesis of this phenomenon remains uncertain. Both skeletal muscle catabolism and renal tubular cell dysfunction have been proposed to explain this observation. We have investigated urinary zinc and N-acetyl-β-d-glucosaminidase (NAG), an indicator of renal tubular cell dysfunction, as well as serum neopterin, an index of systemic immune activation, in 22 patients with cancer and seven controls. Both serum neopterin and urinary zinc were significantly elevated in cancer patients (15.8 ± 12.7 versus 7.3 ± 2.3 nmol l−1 and 1.77 ± 0.80 versus 1.21 ± 0.41 mmol mol−1 creatinine, P < 0 and P < 0.05, respectively), while NAG was similar in cancer patients and the controls (13.58 ± 13.80 versus 13.68 ± 12.19 μkat mol−1 creatinine). A significant correlation was observed between serum neopterin and urine zinc (rs = 0.5119, P < 0.02), serum neopterin and urine NAG (rs = 0.6761, P < 0.002), and urinary zinc and NAG (rs = 0.6348, P < 0.002). In conclusion, the present data indicate a link between urinary zinc excretion and immune activation as well as renal tubular cell dysfunction. In addition, renal tubular cell dysfunction appears to be linked to immune activation.

Keywords

cancer N-acetyl-β-d-glucosaminidase neopterin urine zinc 

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Copyright information

© Rapid Communications of Oxford Ltd 1995

Authors and Affiliations

  • Bohuslav Melichar
    • 1
  • František Malíř
    • 5
  • Pavel Jandík
    • 2
  • Eva Malířová
    • 3
  • Jaroslava Vávrová
    • 4
  • Jindřiška Mergancová
    • 2
  • Zbyněk Vobořil
    • 2
  1. 1.Second Department of Internal MedicineCharles University Medical SchoolCzech Republic
  2. 2.Department of SurgeryCharles University Medical SchoolCzech Republic
  3. 3.Department of Nuclear MedicineCharles University Medical SchoolCzech Republic
  4. 4.Department of Clinical ChemistryCharles University Medical SchoolCzech Republic
  5. 5.Xenobiochemic LaboratoryHradecCzech Republic

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