European Journal of Epidemiology

, Volume 7, Issue 5, pp 466–468 | Cite as

Risk of Creutzfeldt-Jakob disease in relation to animal spongiform encephalopathies: A collaborative study in Europe

  • A. Hofman
Article

Abstract

This paper describes a study of the risk of Creutzfeldt-Jakob disease in various European countries. The objectives of the study are to investigate the frequency of Creutzfeldt-Jakob disease and other human spongiform encephalophaties in Europe in relation to animal spongiform encephalophaties, and to assess the risk of Creutzfeldt-Jakob disease in relation to genetic, occupational and nutritional factors. The study will consist of three parts: the establishment of registries of Creutzfeldt-Jakob disease on the basis of cases in the registries, and molecular genetic studies with material collected in the registries.

Key words

Creutzfeldt-Jakob disease Animal spongiform encephalopathy Bovine spongiform encephalopathy Risk factors Europe 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    BobowichA.R, BrodyJ.A, MatthewsM.R, RoosR. and GajdusekD.C (1973): Creutzfeldt-Jakob disease: A case-control study. - Am. J. Epidemiol. 98: 381–394.Google Scholar
  2. 2.
    BrownP., CathalaF., RaubertasR.F., CajdusekD.C. and CataigneP. (1987): The epidemiology of Creutzfeldt-Jakob disease: Conclusion of a 15-year investigation in France and review of the world literature. - Neurology 895: 895–904.Google Scholar
  3. 3.
    Brown P. (1988): The clinical neurology and epidemiology of Creutzfeldt-Jakob disease, with special reference to iatrogenic cases. In: Ciba Foundation, ed. Novel Infectious Agents and the Central Nervous System. - John Wiley Sons, 318.Google Scholar
  4. 4.
    DavampourZ., AlterM., SobelE., AsherD.M. and GajdusekD.C. (1985): A case-control study of Creutzfeldt-Jakob disease: dietary risk factors. - Am. J. Epidemiol. 122: 443–451.Google Scholar
  5. 5.
    GibbsC.J., GajdusekD.C, AsherD.M., AlpersH.P., BeckE., DanielP.M. and MatthewsW.B. (1968): Creutzfeldt-Jakob disease (spongiform encephalopathy): transmission to the chimpanzee. -Science 161: 388–389.Google Scholar
  6. 6.
    Goldfarb L.G., Korczyn A.D., Brown P., Chapman J. and Gajdusek D.C. (1990): Mutation in codon 200 of scrapie amyloid precursor gene linked to Creutzfeldt-Jakob disease in Sephardic Jews of Libyan and non-Libyan origin (Letter). - Lancet 637–638.Google Scholar
  7. 7.
    Goldfarb L.G., Mitrova E., Brown P., Toh B.H. and Gajdusek D.C. (1990): Mutation in codon 200 of scrapie amyloid protein gene in two clusters of Creutzfeldt-Jakob disease in Slovakia (Letter). -Lancet 514–515.Google Scholar
  8. 8.
    GoldgaberD., GoldfarbL.G., BrownP., AsherD.M., BrownW.T., LinS., TeenerJ.W., FeinstoneS.M., RubensteinR., KascsakR.J., BoellaardJ. W. and GajdusekD.C. (1989): Mutations in familial Creutzfeldt-Jakob disease and Gerstmann-Sträussler Scheinker's syndrome. - Experimental Neurol. 106: 204–206.Google Scholar
  9. 9.
    Harries-JonesR., KnightR., WillR.G., CousensS., SmithP.G. and MatthewsW.B. (1988): Creutzfeldt-Jakob disease in England and Wales, 1980–1984: a case-control study of potential risk factors. - J. Neurol. Neurosurg. Psych. 51: 1113–1119.Google Scholar
  10. 10.
    KimberlinR.H., ColeS. and WalkerC.A. (1990): Temporary and permanent modifications to a single strain of mouse scrapie on transmission to rats and hamsters. - Journal of General Virology 68(7):1875–1881.Google Scholar
  11. 11.
    KondoK. and KuroiwaY. (1982): A case-control study of Creutzfeldt-Jakob disease: association with physical injuries. - Ann. Neurol. 11: 377–381.Google Scholar
  12. 12.
    Southwood Committee. (1989): Report of the Working Party on Bovine Spongiform Encephalopathy. Department of Health and Ministry of Agriculture, Fisheries and Food. - ISBN 185197 405 9.Google Scholar

Copyright information

© Gustav Fischer 1991

Authors and Affiliations

  • A. Hofman
    • 1
  1. 1.Department of EpidemioloGy and BiostatisticsErasmus University Medical SchoolDR RotterdamThe Netherlands

Personalised recommendations