Synthesis of Fmoc-amino acid fluorides via DAST, an alternative fluorinating agent

Christine Kaduk; Holger Wenschuh; Michael Beyermann; Klaus Forner; Louis A. Carpino; Michael Bienert

doi:10.1007/BF00142240

Letters in Peptide Science

January 1996, Volume 2, Issue 5, pp 285–288

Synthesis of Fmoc-amino acid fluorides via DAST, an alternative fluorinating agent

Authors
Authors and affiliations

Christine Kaduk
Holger Wenschuh
Michael Beyermann
Klaus Forner
Louis A. Carpino
Michael Bienert

Article

Received:: 25 September 1995
Accepted:: 11 October 1995

DOI: 10.1007/BF00142240

Cite this article as:: Kaduk, C., Wenschuh, H., Beyermann, M. et al. Lett Pept Sci (1996) 2: 285. doi:10.1007/BF00142240

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Summary

DAST [(diethylamino)sulfur trifluoride] has shown to be an excellent alternative fluorinating agent for synthesis of Fmoc-amino acid fluorides. The use of DAST is advantageous relative to other fluorinating agents, such as cyanuric fluoride, since handling and isolation of the acid fluorides are facile.

Keywords

Amino acid fluorides Coupling reagents Fluorination Solid phase synthesis

References

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Authors and Affiliations

Christine Kaduk
- 1
Holger Wenschuh
- 1
Michael Beyermann
- 1
Klaus Forner
- 1
Louis A. Carpino
- 1
Michael Bienert
- 1

1.Institute of Molecular PharmacologyBerlinGermany
2.Department of ChemistryUniversity of MassachusettsAmherstU.S.A.

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Synthesis of Fmoc-amino acid fluorides via DAST, an alternative fluorinating agent

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