Synthesis, characterization and antitumour studies of metal chelates of acetoacetanilide thiosemicarbazone
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Summary
Complexes of transition metals with acetoacetanilide thiosemicarbazone, AatH2, have been prepared and characterized. The complexes were found to have the following stoichiometries: [Mn(Aat)(H2O)2]n; [Zn(Aat)(H2O)2]; [M(Aat)(H2O)], where M = CdII or HgII; [Cu(Aat)]n; [Ag(AatH)]; [M(AatH)2], where M = CoII or NiII, and [Fe(Aat)Cl(H2O)]n. The compounds have been studied for their possible antitumour activity against Ehrlich Ascites tumour cells in vitro.
Keywords
Tumour Cell Physical Chemistry Inorganic Chemistry Metal Chelate Thiosemicarbazone
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