Biotechnology Letters

, Volume 16, Issue 8, pp 831–836

High production of 1,3-propanediol from glycerol by Clostridium butyricum VPI 3266 in a simply controlled fed-batch system

  • S. Saint-Amans
  • P. Perlot
  • G. Goma
  • P. Soucaille
Article

Summary

A simple fed-batch system which controls substrate feeding by measuring the CO2 produced during the fermentation, was developped. This Fed-batch approach allowed high production of 1,3-propanediol from glycerol by Clostridium butyricum by avoiding substrate inhibition phenomena. 65 g/l of 1,3-propanediol was produced with a productivity of 1.21 g/l.h and a yield of 0.56. The concentration of 1,3-propanediol obtained and the productivity were significantly higher than those reached in batch culture.

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Copyright information

© Chapman & Hall 1994

Authors and Affiliations

  • S. Saint-Amans
    • 1
  • P. Perlot
    • 1
  • G. Goma
    • 1
  • P. Soucaille
    • 1
  1. 1.Institut National des Sciences Appliquées, Centre de Bioingénierie Gilbert Durand, URA CNRS 544, L.A.INRA. Complexe Scientifique de RangueilToulouse CedexFrance

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