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Clinical & Experimental Metastasis

, Volume 10, Issue 3, pp 191–199 | Cite as

Comments on hematogenous metastatic patterns in humans as revealed by autopsy

  • Leonard Weiss
Article

An attempt is made to clarify some general concepts of hematogenous metastatic patterns in humans, by the use of autopsy data. The significance and problems associated with ‘false negative’ reports are assessed. By the use of metastatic efficiency indices in which the incidence of specific target organ involvement is related to organ blood-flow, ‘seed-and-soil’ effects are discriminated from the effects of differential cancer cell delivery. An analysis of autopsy data from cases with a history of colorectal carcinoma is used to illustrate the importance of metastasis from metastases in the genesis of hematogenous metastatic patterns in humans.

Keywords

human hematogenous metastatic patterns 

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References

  1. 1.
    Ewing J. Metastasis. In:Neoplastic Diseases: a treatise on tumours, 3rd edn, Chapter 4. Philadelphia: Saunders, 1928.Google Scholar
  2. 2.
    Schmelzer PL and Briggs GL, eds, 1984, College of American Pathologists Foundation Conference on the Autopsy.Archives of Pathology and Laboratory Medicine,108, 437–523.Google Scholar
  3. 3.
    Paget S, 1989, The distribution of secondary growths in cancer of the breast.Lancet,i, 571–573.Google Scholar
  4. 4.
    Weiss L.Principles of Metastasis p.232. Orlando, FL: Academic Press, 1985.Google Scholar
  5. 5.
    McCormack P. Surgical treatment of pulmonary metastases: memorial hospital experience. In: Weiss L and Gilbert HA, eds.Pulmonary Metastasis, pp. 260–270. Boston: GK Hall, 1978.Google Scholar
  6. 6.
    Weiss L and Harlos JP, 1986, The validity of negative necropsy reports for metastases in solid organs.Journal of Pathology,148, 203–206.Google Scholar
  7. 7.
    Weiss L.Principles of Metastasis, p. 217. Orlando, FL: Academic Press, 1985.Google Scholar
  8. 8.
    Weiss L.Principles of Metastasis, p. 162. Orlando, FL: Academic Press, 1985.Google Scholar
  9. 9.
    Weiss L, Grundmann E, Torhorst J, Hartveit F, Moberg I, Eder M, Fenoglio-Preiser CM, Napier J, Horne CHW, Lopez MJ, Shaw-Dunn RI, Sugar J, Davies JD, Day DW and Harlos JP, 1986, Haematogenous metastatic patterns in colonic carcinoma: an analysis of 1541 necropsies.Journal of Pathology,150, 195–203.Google Scholar
  10. 10.
    Weiss L.Principles of Metastasis, p. 261. Orlando, FL: Academic Press, 1985.Google Scholar
  11. 11.
    Weiss L, Harlos JP, Torhorst J, Gunthard B, Hartveit F, Syendsen E, Huang W-L, Grundmann E, Eder M, Zwicknagl M, Cochrane HR, Stock D, Wright C and Horne CHW, 1988, Metastatic patterns of renal carcinoma: an analysis of 687 necropsies.Journal of Cancer Research and Clinical Oncology,114, 605–612.Google Scholar
  12. 12.
    Abrams HL, Spiro R and Goldstein N, 1958, Metastases in carcinoma. Analysis of 1000 autopsied cases.Cancer,30, 74–85.Google Scholar
  13. 13.
    Elliott JA, Osterlind K, Hirsch FR and Hansen HH, 1987, Metastatic patterns in small-cell lung cancer: correlation of autopsy findings with clinical parameters in 537 patients.Journal of Clinical Oncology,5,246–254.Google Scholar
  14. 14.
    Jeffree GM, Price CHG and Sissons H, 1975, The metastatic patterns of osteosarcoma.British Journal of Cancer,32, 87–107.Google Scholar
  15. 15.
    Rose PG, Piver MS, Tsukada Y and Lau T, 1989, Metastatic patterns in histologic variants of ovarian cancer. An autopsy study.Cancer,64, 1508–1513.Google Scholar
  16. 16.
    Weiss L, Harlos JP, Hartveit F, Maartmann-Moe, Svendsen E, Christen S, Torhorst J, Horne CHW and Johnson SJ, 1992, Regional Cancer Treatment. (In press).Google Scholar
  17. 17.
    17. Saitoh H, Hida M, Shimbo T, Nakamura K, Yamagata J and Satoh T, 1984, Metastatic patterns of prostatic cancer. Correlation between sites and number of organs involved.Cancer,54, 3078–3084.Google Scholar
  18. 18.
    Weiss L, Ward PM, Harlos JP and Holmes JC, 1984, Target organ patterns or tumors in mice following the arterial dissemination of B16 melanoma cells.International Journal of Cancer,33, 825–830.Google Scholar
  19. 19.
    Weiss L, Haydock K, Pickren JW and Lane WW, 1980, Organ vascularity and metastatic frequency.American Journal of Pathology,101, 101–114.Google Scholar
  20. 20.
    Onuigbo WIB. Historical concepts of cancer metastasis with special reference to bone. In: Weiss L and Gilbert HA, eds.Bone Metastasis, pp. 1–10. Boston: GK Hall, 1981.Google Scholar
  21. 21.
    Willis RA. The Spread of Tumours in the Human Body, pp. 175–176. London: Butterworth, 1952.Google Scholar
  22. 22.
    Roberts SS. Spread by the vascular system. In: Cole WH, McDonald GO, Roberts SS and Southwick HW, eds.Dissemination of Cancer, pp. 204–205. New York: Appleton-Century-Crofts, 1961.Google Scholar
  23. 23.
    Bross IDJ, Viadana E and Pickren JW, 1975, Does generalized metastasis occur directly from the primary?Journal of Chronic Diseases,28, 149–159.Google Scholar
  24. 24.
    Viadana E, Bross IDJ and Pickren JW, 1978, The metastatic spread of cancers of the digestive system in man.Oncology,35, 114–126.Google Scholar
  25. 25.
    Weiss L, 1990, Metastatic inefficiency.Advances in Cancer Research,54, 159–211.Google Scholar
  26. 26.
    Orr FW, Buchanan MR and Weiss L. Microcirculation in Cancer Metastasis. Boca Raton, FL: CRC Press, 1991.Google Scholar
  27. 27.
    Weiss L, Ward PM and Holmes JC, 1983, Liver-to-lung traffic of cancer cells.International Journal of Cancer,32, 79–83.Google Scholar
  28. 28.
    Ramming KP, Holmes EC, Skinner DG and Morton DL. Surgery for pulmonary metastases: the UCLA approach. In: Weiss L and Gilbert HA, eds.Pulmonary Metastasis, pp. 252–259. Boston: GK Hall, 1978.Google Scholar
  29. 29.
    Takita H, Edgerton F, Vincent RG and Gutierrez AC. Surgical management of lung metastases. In: Weiss L and Gilbert HA, eds.Pulmonary Metastasis, pp. 243–251. Boston: GK Hall, 1978.Google Scholar
  30. 30.
    Vincent RG, Choksi LB, Takita H and Gutierrez AC. Surgical resection of the solitary pulmonary metastasis. In: Weiss L and Gilbert HA, eds.Pulmonary Metastasis, pp. 232–242. Boston: GK Hall, 1978.Google Scholar
  31. 31.
    Wilkens EW. The status of pulmonary resection of metastases: experience at Massachusetts General Hospital. In: Weiss L and Gilbert HA, eds.Pulmonary Metastasis, pp. 271–281. Boston: GK Hall, 1978.Google Scholar
  32. 32.
    Steel GG.Growth Kinetics of Tumours, pp. 48–49. Oxford: Clarendon Press, 1977.Google Scholar
  33. 33.
    Weiss L and Mayhew E, 1985, An approach to the therapy of metastases from cancer of the upper rectum: a working hypothesis.Cancer Drug Delivery,2, 19–33.Google Scholar
  34. 34.
    Aigner KR, Walther H and Link KH. Isolated liver perfusion with MMC/5-FU-Surgical technique, pharmacokinetics, clinical results. In: Aigner KR, Patt YZ, Link KH and Kreidler J, eds.Regional Cancer Treatment, pp. 229–246. Basel: Karger, 1988.Google Scholar

Copyright information

© Rapid Communications of Oxford Ltd 1992

Authors and Affiliations

  • Leonard Weiss
    • 1
  1. 1.Department of Experimental PathologyRoswell Park Memorial InstituteBuffaloUSA

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