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Biotechnology Letters

, Volume 18, Issue 12, pp 1419–1422 | Cite as

Lipase-catalyzed resolution of primary alcohol containing quaternary chiral carbon

  • Chan Seong Cheong
  • Dai Sig Im
  • Jiyoung Kim
  • In O Kim
Article

Summary

2-Cyano-2-phenyl-1-hexanol containing chiral quaternary carbon was resolved using a lipase. Among various reaction conditions, transesterification reaction (solvent; n-hexane, lipase; Candida cylindracea) gave high selectivity(20/80). Additionally, the selectivity could be improved(13/87) when pyridine(1%) was used as an additive. The ratios of resolved alcohols were determined by GC and 1H-NMR analysis using Mosher's derivative.

Keywords

Alcohol Organic Chemistry Lipase Pyridine Candida 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Chapman & Hall 1996

Authors and Affiliations

  • Chan Seong Cheong
    • 1
  • Dai Sig Im
    • 1
  • Jiyoung Kim
    • 1
  • In O Kim
    • 1
  1. 1.Division of Applied ScienceKorea Institute of Science and TechnologySeongbuk-ku, SeoulKorea

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